An efficient chiral squaramide-catalysed enantioselective Michael addition of pyrazolin-5-ones to nitroalkenes has been developed. This reaction afforded the chiral pyrazol-3-ol derivatives in high to excellent yields (up to >99%) with high enantioselectivities (up to 94% ee) for most substrates under very low catalyst loading (0.25 mol%). This catalytic asymmetric reaction provides valuable an...

Background: Mothers of preterm neonates are more sensitive to their baby's health than other mothers, and this causes them worry and anxiety. Meanwhile, the possibility of facing Covid-19 may increase their worries and anxiety and leave negative effects on their role as mothers. This study aims to determine the relationship between maternal fear and anxiety about Covid-19 and maternal role atta...

background: fear of falling is common amongst older adults, especially those who live in nursing homes. this study aimed to determinate factors associated with fear of falling and functional independence in older adults living in nursing homes. methods: this was a cross-sectional study using a convenience sampling method to enroll 200 older adults living in nursing homes from 25 senior centers ...

Individual differences in observed and maternal-rated fear behaviors and frontal electroencephalogram (EEG) asymmetry were examined in normally developing 10-month-old infants. EEG was recorded during resting baseline, as well as during stranger approach, mask presentation, and toy spider presentation. Mothers completed the Infant Behavior Questionnaire. For mask presentation, baseline and task...

Fear is a graded central motive state ranging from mild to intense. As threat intensity increases, fear transitions from discriminative to generalized. The circuit mechanisms that process threats of different intensity are not well resolved. Here, we isolate a unique population of locally projecting neurons in the central nucleus of the amygdala (CeA) that produce the neuropeptide corticotropin...