BACKGROUND The degree of conversion (DC) of resin based materials depends, beside other factors, on the light-intensity applied during light curing. A lower DC might be correlated with an increased cytotoxicity of the respective materials. Therefore, aim of the present study was to investigate the influence of the distance between light-curing tip and adhesives on their cytotoxicity and degree ...

Arsenic trioxide (ATO) has been found to exert anti-cancer activity in various human malignancies. However, the molecular mechanisms by which ATO inhibits tumorigenesis are not fully elucidated. In the current study, we explored the molecular basis of ATO-mediated tumor growth inhibition in pancreatic cancer cells. We used multiple approaches such as MTT assay, wound healing assay, Transwell in...

PURPOSE A facile method was established to enzymatically synthesize rhapontigenin from the glycosylated parent compound rhaponticin. A novel and simple high-performance liquid chromatographic method was developed for the determination of rhapontigenin. The assay was successfully applied to both the in vitro and in vivo metabolic kinetic study of rhapontigenin. METHODS Serum, or microsomes (0....

BACKGROUND Influenza virus attaches to sialic acid residues on the surface of host cells via the hemagglutinin (HA), a glycoprotein expressed on the viral envelope, and enters into the cytoplasm by receptor-mediated endocytosis. The viral genome is released and transported in to the nucleus, where transcription and replication take place. However, cellular factors affecting the influenza virus ...

For two given graphs G1 and G2, the Ramseynumber R(G1,G2) is the smallest integer n such that for anygraph G of order n, either $G$ contains G1 or the complementof G contains G2. Let Tn denote a tree of order n andWm a wheel of order m+1. To the best of our knowledge, only R(Tn,Wm) with small wheels are known.In this paper, we show that R(Tn,Wm)=3n-2 for odd m with n>756m^{10}.

The analysis of chromosome aberration in peripheral blood lymphocytes is a sensitive and frequently applied method to assess the individual dose following accidental, occupational or medical exposure to ionizing radiation. According to the standard protocol [1], lymphocytes are cultured in vitro for 48 h. Then, metaphases are harvested and chromosome aberrations are scored with the expectation ...

Correspondence: Jennifer J Hu sylvester Comprehensive Cancer Center, University of Miami Miller school of Medicine, 1120 nW 14th st., CRB 1511, Miami, FL 33136, UsA Tel +1 305 243 3356 Fax +1 305 243 2997 email [email protected] Abstract: Genetic variations in cell cycle checkpoints and DNA repair genes are associated with prolonged cell cycle G 2 delay following ionizing radiation (IR) treatme...

BACKGROUND Seaweeds are taxonomically diverse benthic algae, which are rich in bioactive compounds. These compounds have a potential application in medicine. OBJECTIVES The aim of the study was to investigate the bioactive properties of three seaweed samples, Enteromorpha antenna, Enteromorpha linza and Gracilaria corticata were collected from the shoreline of Mahabalipuram, Tamilnadu. MATE...

DNA-damaging agents are commonly used for first-line chemotherapy of advanced non-small cell lung cancer (NSCLC). As a G2/M checkpoint kinase, Wee1 can phosphorylate CDC2-tyr15 and induce G2/M cell cycle arrest in response to DNA damage. The correlation of WEE1 polymorphisms to the efficacy of chemotherapy was tested in 663 advanced NSCLC patients. WEE1 rs3910384 genotype correlated to overall ...