BACKGROUND/AIMS Nonalcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease worldwide. Along with the increase in the incidence of NAFLD and associated obesity, an increase in gallbladder disease (GD) has been noted. This has led to the identification of a new disease entity called fatty GD. There is a gap in the literature on the dynamics of gallbladder function...

Background Kras mutations and increased Notch activation occur frequently in gallbladder cancer. However, their roles in gallbladder carcinogenesis have not been defined. This study was aimed at determining whether expression of mutant Kras was sufficient to induce gallbladder carcinoma and whether Notch deregulation played a role in this context. Methods We determined Cre recombination activ...

OBJECTIVE To evaluate the prognostic factors of gallbladder carcinoma. METHODS Presentation, operative data, complications, and survival outcome were examined for 132 gallbladder carcinoma patients who underwent gallbladder surgery in our unit during 2002-2007, and follow-up results were obtained from every patient for univariate and multivariate survival analysis. RESULTS The univariate an...

Background & Aims: Calcifying nanoparticles are different forms of calcium and phosphate in sediments. Recent evidence suggests that calcifying nanoparticles (CNPs) are probably selfreplicating. Several diseases are linked to nano-bacteria including kidney stones, gallbladder stone, cardiovascular plaques, oral–dental plaque, many cancers, and autoimmune diseases. The aim of this study was to a...

There are three common types of gallbladder disorders, Cholelithiasis, Cholecystitis, and Functional Gallbladder Disorder. Cholelithiasis is a disease characterized by the formation of gallstones and/or the accumulation of biliary sludge in the gallbladder or cystic duct. Cholecystitis is a disease characterized by chronic or acute infection and inflammation of the gallbladder. Functional gallb...

Sarcoma of the gallbladder is a rare entity. This report presents an extremely rare clinical case of a neurofibrosarcoma of the gallbladder. On examination, a mass was felt in the right hypochondrium. An ultrasound of the abdomen showed a mass in the gallbladder. Computed tomography (CT) scan of the abdomen showed a grossly distended gallbladder with soft tissue mass in the gallbladder. The mas...

We describe the first known use of volume-controlled bronchopulmonary lavage in a case of alveolar microlithiasis. Although the procedure has often been discussed in the literature as theoretically useful in the therapy for this disease, in our case it showed no efficacy in clearing the alveolar spherules.

INTRODUCTION True left-sided gallbladder (LSG) is a rare finding that may present with symptoms similar to those of a normally positioned gallbladder. Moreover, it may be missed by preoperative imaging studies such as ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), or endoscopic ultrasound. True left-sided gallbladder is a surgical challenge and surgical technique may ne...

  Introduction: Despite presence of a body of evidence in support of high accuracy of cholecystokinin cholescintigraphy (CCK-CS) , for diagnosis of chronic cholecystitis(CC) , some authors have claimed that  gallbladder ejection fraction (GBEF)  has poor predictive diagnostic values. The purpose of this study was to determine if there is any difference in GBEF between...

BACKGROUND Gallbladder adenomyomatosis is a benign condition characterized by hyperplastic change in the gallbladder wall and overgrowth of the mucosa because of an unknown cause. Patients with gallbladder adenomyomatosis usually present with abdominal pain. However, we herein describe a case of a patient with gallbladder adenomyomatosis who did not present with abdominal pain, but with only fe...