Introducción: Se evaluará el uso de la hormona adrenocorticotropa como tratamiento del síndrome West (síndrome Lennox-Gastaut) y tiempo requerido para progresión hacia evolución grave. Existen escasos datos sobre esta patología nuestra población. Material Métodos: trata una cohorte donde se analizaron 139 historias clínicas pacientes evaluados en dos unidades pediatría ciudad Lima entre los año...

Developmental and epileptic encephalopathies (DEEs) are among the most challenging of all epilepsies to manage, given exceedingly frequent often severe seizure types, pharmacoresistance conventional antiseizure medications, numerous comorbidities. During past decade, efforts have focused on development new treatment options for DEEs, with several recently approved in United States or Europe, in...

An observational study of all children with intractable epilepsy at the Paediatric Institute prescribed Lamotrigine as an add-on therapy between January 1994 and November 1998 was conducted. A total of 30 children were recruited. Three had adverse effects to the drug and it was withdrawn. Of the remaining 27, there were 20 boys and 7 girls, ranging from 2 to 17 years. Fifteen children had gener...

Mental retardation is detected in 20-30% of children with epilepsy at hospitals specializing in treatment of childhood epilepsy. However, the incidence of mental deterioration in childhood epilepsy is not high. In this study, mental deterioration was found in 52 (1.8%) of the 2,880 children with epilepsy at Okayama University Hospital. The patients showing mental deterioration mostly suffered f...

Lennox-Gastaut syndrome (LGS) is a rare but debilitating pediatric epileptic encephalopathy characterized by multiple intractable seizure types. Treatment of LGS is challenging because of the small number of antiepileptic drugs (AEDs) which are effective for this syndrome, as well as the need for polytherapy in the majority of patients. This review focuses on the treatment of LGS with rufinamid...

The characteristic electroclinical features of Lennox-Gastaut syndrome (LGS) have been extensively reported, but the influence of the constellation of slow spike-and-wave (SSW) complexes with multiple seizure types (including atypical absence seizures [AAS] and tonic seizures [TS]) on patients with this syndrome is still unclear. We report the case of a 28-year-old woman who developed AAS and b...