Photoreceptor rod outer segment membrane guanylate cyclase (ROS-GC) is central to visual transduction; it generates cyclic GMP, the second messenger of the photon signal. Photoexcited rhodopsin initiates a biochemical cascade that leads to a drop in the intracellular level of cyclic GMP and closure of cyclic nucleotide gated ion channels. Recovery of the photoresponse requires resynthesis of cy...

Chloroplast division is an important cellular process, which involves complicated coordination of multiple proteins. In mutant plants with chloroplast division defects, chloroplasts are usually found to be with enlarged size and reduced numbers. Previous studies have shown that AT2G21280, which was named as GC1 (GIANT CHLOROPLAST 1) or AtSulA, was an important chloroplast division gene, because...

The paralytic shellfish toxin (PST)-producing dinoflagellate Gymnodinium catenatum grows in association with a complex marine bacterial community that is both essential for growth and can alter culture growth dynamics. Using a bacterial community replacement approach, we examined the intracellular PST content, production rate, and profile of G. catenatum cultures grown with bacterial communitie...

Abstract Study question Does IGF2BP3 regulate Tcf4 mRNA stability in an N6-methyladenosine (m6A)-dependent manner, affect spermatogenesis, and lead to idiopathic non-obstructive azoospermia (iNOA)? Summary answer induces apoptosis of spermatogenic cells by regulating the m6A-dependent which turn affects spermatogenesis leading iNOA. What is known already Azoospermia most serious phenotype male ...

Epileptiform abnormalities contribute to progressive deterioration of cerebral function. Considered: Ohtahara Syndrome; Early myoclonic epileptic encephalopathy; West Syndrome; Dravet Syndrome; Myoclonic status in not progressive encephalopathies; CDKL5 encephalopaty. Ohtahara syndrome (OS) early infantile encephalopathy (EIEE). Most cases linked to cerebral malformations or very occasionally t...

D2 differed from one another by fewer than five single nucleotide differences, but only the WM98 sequence was not interrupted by large insertions or deletions (positions of insertions/deletions are indicated in Figure 1). AB307-0294 (GenBank accession number CP001172) was also identical over most of this span, but contained patches that differed and lacked a large span. The AB0057 sequence (Gen...

in the GenBank non-redundant DNA database was examined. Two additional cases of ISAba1 associated with distinct ampC alleles were found in accession numbers EU604835 8 and AY325306. 3 In both of them, the IS was again in the same orientation and separated from the ATG initiation codon of ampC by 9 bp. The number of single nucleotide differences between the various ampC alleles is shown in Table...

UNLABELLED Codon usage bias (CUB) is an omnipresent phenomenon, which occurs in nearly all organisms. Previous studies of codon bias in Plasmodium species were based on a limited dataset. This study uses whole genome datasets for comparative genome analysis of six Plasmodium species using CUB and other related methods for the first time. Codon usage bias, compositional variation in translated a...

Sir, Worldwide, resistance to carbapenems, imipenem and meropenem is widespread among Acinetobacter causing infections and most resistant isolates are also resistant to many other antibiotic classes. Several class D b-lactamases can hydrolyse carbapenems, conferring resistance. The blaOXA-23 gene was the first to be found and was originally identified in a conjugative plasmid from a clinical Ac...