A Mallory body (alcoholic hyaline) antigen (JMB2) which is also present in intermediate filaments of epithelial origin was demonstrated immunohistochemically in renal glomeruli of three out of eleven patients with alcoholic liver damage. In two of these patients, both of whom had alcoholic cirrhosis with Mallory bodies, it was associated with mesangial deposits of IgA and C3. JMB2 was not found...

neurons (two in green, one in red) stained in the same preparation by intracellular iontophoresis of Alexa fluor and imaged with confocal microscopy. Each projection neuron sends 8 –12 radial dendrites that each terminate in one of about 1,000 glomeruli. All the glomeruli sampled by each projection neuron are coplanar and the 1,000 glomeruli together fill an approximately spherical volume. Each...

Background: Kidney disorders are serious outcomes of diabetes, resulting in renal ailments. This study seeks to provide an alternative treatment for the disorder through the use of medicinal plants that offer renal protection and ameliorate the deleterious effect of diabetes. Methods: Thirty rats were divided into six groups of five and hyperglycemia was induced by intraperitoneal injection ...

473 Physiological experiments have shown that odors evoke spatially organized activity patterns in both the vertebrate olfactory bulb1–6 and the insect antennal lobe7–12. Evidence is mounting that this spatial organization is conserved within a species: in rodents, axons of receptor neurons expressing the same receptor gene converge to equivalent positions in different individuals13. Physiologi...

It is accepted that sensory experience instructs the remodelling of neuronal circuits during postnatal development, after their specification has occurred. The story is less clear with regard to the role of experience during the initial formation of neuronal circuits, whether prenatal or postnatal, since this process is now supposed to be primarily influenced by genetic determinants and spontan...

The accumulation of AGEs (advanced glycation end products) in diabetes mellitus has been implicated in the biochemical dysfunction associated with the chronic development of microvascular complications of diabetes--nephropathy, retinopathy and peripheral neuropathy. We investigated the concentrations of fructosyl-lysine and AGE residues in protein extracts of renal glomeruli, retina, peripheral...

ICR-derived strain with glomerulonephritis (ICGN) is a strain of mice with hereditary nephrotic syndrome with an unidentified cause. Based on histopathological and biochemical data, ICGN mice are considered to be a good experimental model for human idiopathic nephrotic syndrome. In the present study, we histochemically investigated the changes in localization of extracellular matrix (ECM) compo...

BMP, activin, membrane-bound inhibitor (BAMBI) acts as a pseudo-receptor for the transforming growth factor (TGF)-β type I receptor family and a negative modulator of TGF-β kinase signaling, and BAMBI(-/-) mice show mild endothelial dysfunction. Because diabetic glomerular disease is associated with TGF-β overexpression and microvascular alterations, we examined the effect of diabetes on glomer...

Glomeruli within the antennal lobe (AL) of moths are convergence sites for a large number of olfactory receptor neurons (ORNs). The ORNs target single glomeruli. In the male-specific cluster of glomeruli, the macroglomerular complex (MGC), the input is chemotypic in that each glomerulus of the MGC receives information about a specific component of the conspecific female sex pheromone. Little is...

Individual glomeruli in the mammalian olfactory bulb (OB) most probably represent a single odorant receptor (OR). The assembly of glomeruli thus forms the maps of ORs. How is the approximately 1,000 ORs represented spatially in the glomerular map? Using the method of optical imaging of intrinsic signals and systematic panels of stimulus odorants, we recorded odorant-induced glomerular activity ...