stereologic methods are used to abtain quantitative information about 3-dimensional structures from histologic sections. the aim of the present study was using new and unbiased stereologic techniques to investigate changes in volume and number of glomeruli after chronic lead acetate intoxication both quantitatively and in 3-dimensional spaces.lead is one of the heavy metals that has adverse eff...

introduction: due to the relation between structure and function of renal glomeruli, the study of glomeruli is very important to the understanding of initiation and progression of diabetic glomerulopathy. it seems that glomeruli disappear during the course of diabetic nephropathy without leaving recognizable corpuscles. this study was aimed to show diabetes mellitus effects on changes in renal ...

Olfactory glomeruli are innervated with great precision by the axons of different olfactory sensory neuron types and act as functional units in odor information processing. Approximately 140 glomeruli are present in each olfactory bulb of adult zebrafish; these units consist of either highly stereotypic large glomeruli or smaller anatomically indistinguishable glomeruli. In the present study, w...

Nephrotic syndrome (NS) is a rare, serious and debilitating kidney condition, caused by range of different diseases that damage the glomeruli. The condition affects around 1 in 30,000 UK adults per year?[1]?. Glomeruli are found kidneys filter fluid, electrolytes waste products from blood, while preventing loss protein, […]

To elucidate the involvement of cyclooxygenase (COX) in degradation of aggregated protein in diabetic glomeruli, we used streptozotocin (STZ)-induced diabetic mice and aggregated bovine serum albumin (a-BSA) as a model protein. There was a higher deposition of a-BSA in diabetic glomeruli compared to normal glomeruli 18 h after a-BSA injection at 4 and 8 weeks after STZ. Degradation of a-BSA was...

Glomeruli are anatomical and possibly functional modules in the vertebrate olfactory bulb. We investigated the spatial arrangement of glomeruli in the olfactory bulbs of adult zebrafish (Brachydanio rerio). A solution of the lipophilic tracer Dil was injected into the nasal cavities. Axons of sensory neurons projecting from the olfactory epithelium into the bulb were traced anterogradely, thus ...

The surface of the mammalian olfactory bulb (OB) is covered by numerous glomeruli. Since individual glomeruli represent a single odorant receptor (OR) among a repertoire of nearly 1000 ORs, the spatial assembly of the glomeruli forms the maps of ORs. How are the numerous ORs represented spatially in the glomerular maps? Studies of mapping of odorant-induced glomerular activity using the optical...

The glomerular sheet of the olfactory bulb (OB) forms odorant receptor maps that are parceled into zones. We previously reported the molecular receptive range (MRR) property of individual glomeruli in the dorsal zone (zone 1) of the OB and showed that polar functional groups play a major role in activating glomeruli in this zone. However, the MRR property of glomeruli in zones 2-4 is not well u...