Abstract The implantation of aortic valve prostheses is often associated with the dilation ascending aorta. It well known that modification fluid dynamics induced by both prosthetic and may, in turn, promote further vessel remodelling. Besides, when prosthesis mechanical, a major concern blood cell damage platelet activation which requires lifelong anticoagulant therapy, turn an additional sign...

OBJECTIVE To test the dependency of haemolytic and cytocidal manifestations of pathogenicity of Trichomonas vaginalis on direct contact between the target cells and the organism. TEST ORGANISM: T vaginalis strain Baltimore 42. DESIGN Haemolysis in the presence of live T vaginalis and of its filter-sterilised metabolic products was compared. The dependence of haemolytic and cytocidal effects o...

BACKGROUND Severe anaemia is a major cause of morbidity and mortality in African children. The aetiology is multi-factorial, but interventions have often targeted only one or a few causal factors, with limited success. METHODS AND FINDINGS We assessed the contribution of different pathophysiological mechanisms (red cell production failure [RCPF], haemolysis and blood loss) to severe anaemia i...

Pneumolysin is one of the family of thiol-activatable, cytolytic toxins. Within these toxins the amino acid sequence Trp-Glu-Trp-Trp is conserved. Mutations made in this region of pneumolysin, residues 433-436 inclusive, did not affect cell binding or the formation of toxin oligomers in the target cell membrane. However, the mutations did affect haemolysis, leakage of low-molecular-mass metabol...

1 ORIGINAL ARTICLES 2 ABBREVIATIONS 3 DEFINITIONS 4 INTRODUCTION 5 Patient safety 5 Systems perspective 6 Primary health care 7 Laboratory testing 7 Venous blood sample collection 8 Context for blood sample collection 8 The total testing process 9 The preanalytical phase 11 Patient preparation 11 Patient identification 12 Test request management 12 Test tube labelling 13 Sample collection and h...

CEPHALEXIN, a new semi-synthetic antibiotic derived from cephalosporin C, has the same basic nucleus and the same range of activity as its predecessors, cephalothin and cephaloridine but has the advantage that it can be given orally. As this drug is relatively new, few side-effects have been described. The following case report is of a boy, aged 14 years, who developed acute intravascular haemo...