Hemoglobin (Hb) Ottawa [α15 (A13) Gly→Arg], also known as Hb Siam, was first described in an 82-year-old Canadian in 1974. The same year, a second case was reported in a 28-year-old Chinese male living in Thailand. A third case was found in 1986 in a Chinese female living in the Hubei province of China. Since then, there have been no reports of Hb Ottawa in mainland China in the English literat...

A Bangladeshi family is described in which the genes for both hemoglobin E (Hb E) and pyrimidine 5' nucleotidase deficiency are segregating. An individual homozygous for both these conditions has a severe hemolytic anemia, whereas family members who are homozygous for Hb E are asymptomatic and those homozygous for pyrimidine 5' nucleotidase deficiency have the mild hemolytic anemia that is char...

abstract background prevalence of hereditary blood diseases such as sickle cell anemia, sickle thalassemia and thalassemia major are high in khuzestan province. sickle cell anemia and beta-thalassemia are predominantly common in iranian arabs. pulmonary complications account for a large proportion of morbidity and mortality in patients with and sickle cell disease. periodic lung function assess...

Hemoglobin H-constant spring (Hb H-CS), the most common nondeletional alpha thalassemia in Asia is increasingly recognized in North America due to shifts in immigration patterns. In California, alpha (a)thalassemia syndromes are the second most frequent finding among newborns screened for hemoglobinopathies with a two-fold increase compared to a decade earlier [1,2]. Though known to have a more...

Although beta thalassemia is considered to be a classic monogenic disease, it is clear that there is considerable clinical variability between patients who inherit identical beta globin gene mutations, suggesting that there may be a variety of genetic determinants influencing different clinical phenotypes. It has been suggested that variations in the structure or amounts of a highly expressed r...

Aim and Objective: To evaluate usefulness of Single Tube Osmotic Fragility Test (SOFT) for detection of microcytosis and its further application for thalassemia trait screening. Background: Iron deficiency and thalassemia are common causes of microcytic anaemia in Pakistan. Easy microcytosis screening is necessary at a low resourced country like Pakistan, so that further investigations speciall...

BACKGROUND β-Thalassemia is an inherited hemoglobin disorder caused by defective synthesis of ß-globin chains. Hemoglobin (Hb) F induction is a possible therapeutic approach which can partially compensate for α and non-α globin chains imbalance. OBJECTIVES We aimed to investigate the efficacy and safety of Hydroxyurea (HU) in diminishing transfusion requirements of patients with β-thalassemia...

Background: According to a report of WHO in 2007, 7% world populations are carrier for Haemoglobindisorder and accurate timely detection various Hb variants including beta thalassemia trait can preventoccurrence more serious disorders like major new-borns. But developing country ususe high pressure liquid chromatography (HPLC) is limited, manual testing done assessmentis quite impossible. So, a...

The occurrence of Hb H hydrops fetalis is reported for the first time. The mother has zeta-alpha thalassemia 1 (zeta zeta alpha alpha/----) and the father has non-deletion alpha thalassemia [zeta zeta alpha alpha/zeta zeta (alpha alpha)T]. The complete deletion of the zeta alpha cluster on one chromosome was confirmed by quantitation of alpha and zeta gene numbers, the normal alpha and zeta gen...