The concepts of tolerability and reasonableness are at the core of the International Commission on Radiological Protection (ICRP) system of radiological protection. Tolerability allows the definition of boundaries for implementing ICRP principles, while reasonableness contributes to decisions regarding adequate levels of protection, taking into account the prevailing circumstances. In the 1970s...

The following study presents some possible points of connection between economic policy and environmental protection, partly through practical examples. It also makes an attempt to outline measures inspired by integrated climate while keeping in mind the generally accepted macroeconomic goals, their effects. In doing so, it raises possibility a concept where protection is placed at heart object...

Introduction: Cardiac reperfusion injury is a well-described complication occurring after ischemia or following cardioplegic arrest. The primary aim of this study was to evaluate and compare safety of Mitral valve replacement on beating heart without using cross clamp with the conventional Mitral valve replacement. Material and methods: It was a retrospective observational study for study durat...

Abstract In times of digital pervasion everyday life, the EU has strengthened a normative idea European fundamental rights, especially by referring to strong notion privacy protection. A corridor is evolving with “right privacy” at its heart, right that will be instrumental in shaping legal architecture’s future structure. this Article we argue constitutional protection rights not only individu...

Cardiac hypertrophy, the adaptive response of the heart to overload, is a major risk factor for heart failure and sudden death. Estrogen (E2) and estrogen receptor beta (ERbeta) offer protection against hypertrophy and in the transition to heart failure. However, the underlying pathways remain incompletely defined. We employed a publicly available microarray dataset of female wild-type (WT) and...

Myocardial remodeling and heart failure (HF) are common sequelae of many forms of cardiovascular disease and a leading cause of mortality worldwide. Accumulation of damaged cardiac proteins in heart failure has been described. However, how protein quality control (PQC) is regulated and its contribution to HF development are not known. Here, we describe a novel role for activated protein kinase ...

Protection of heart against ischemia-reperfusion injury by ischemic preconditioning and K(ATP) channel openers is known to involve the mitochondrial ATP-sensitive K(+) channel (mitoK(ATP)). Brain is also protected by ischemic preconditioning and K(ATP) channel openers, and it has been suggested that mitoK(ATP) may also play a key role in brain protection. However, it is not known whether mitoK(...

There is a growing interest for the beneficial effect of magnesium (Mg) in cardiovascular disorders. A number of cardiovascular disorders including myocardial infarction, arrhythmias and congestive heart failure have been associated with low extra- cellular or intracellular concentrations of Mg. The efficiency of the preconditioning effect of Mg on cardiac function and infarct size in the globa...

Objectives: Anti ischemic reperfusion effect of crude methanol extract of Desmodium gangeticum root had been reported earlier but how is modulating its cardiotonic effect to render cardio-protection is largely unknown. Methods: The inotropic effect of methanol extract of Desmodium gangeticum root was investigated on isolated frog heart and further analyzed the physiological and biochemical effe...

Abstract Introduction: Resent studies have been shown beneficial effects of hyperoxia pretreatment against ischemia-reperfusion injury in different organs. The aim of the present study was to investigate early and late effects of normobaric hyperoxia (≥95% O2) pretreatment on ischemia-reperfusion injuries in isolated rat hearts. Methods: Following 60 and 180 minutes of hyperoxia, rat hearts w...