By Bm N S. Bin L AND IRvIN N. KUHN A FORM OF HEMOLYTIC ANEMIA characterized by thrombocytopenia and the presence of fragmented red cells in the peripheral blood has been called microangiopathic hemolytic anemia by Brain, Dacie and Hourihane.’ These workers showed that in this disease the amount of hemoglobinemia and the degree of erythrocyte fragmentation correlated closely with the severity of...

Skalka B.: Antagonistic Effect of Staphylococcus hyicus and Staphylococcus chromogenes Exhibited on Staphylococcal Delta Hemolysin. Acta vet. Bmo, 60,1991: 61-69. Staphylococcus hyicus and Staphylococcus chromo genes are able to inhibit hemolytic effect of the staphylococcal delta hemolysin on agar media supplemented with human or sheep erythrocytes. This inhibition takes place even when the ef...

OBJECTIVES Administration of ethylene glycol monoalkyl ethers to rodents causes acute hemolytic anemia. Metabolic activation of these chemicals to alkoxyacetic acids is required to develop hemolytic effect. Current study was undertaken to compare the hemolytic activity of isopropoxyethanol (IPE) and phenoxyethanol (PhE) in male rats. The main goal of this study was to evaluate the role of alkyl...

Streptococcus mutans is normally alpha- or gamma-hemolytic on blood agar plates. However, three recently isolated S. mutans strains were observed to elicit beta-hemolysis. The production and nature of a hemolytic substance were studied.

The phospholipases C of C. perfringens (alpha-toxin) and C. bifermentans (Cbp) show >50% amino acid homology but differ in their hemolytic and toxic properties. We report here the purification and characterisation of alpha-toxin and Cbp. The phospholipase C activity of alpha-toxin and Cbp was similar when tested with phosphatidylcholine in egg yolk or in liposomes. However, the hemolytic activi...

Studies in this laboratory for the past several years have been focused on the epidemiology of hemolytic streptococcal disease in New Haven. Attention is being given to the incidence and possible clinical and epidemiological significance of the various serological types of hemolytic streptococci recovered from residents of this city. Current experience indicates that in a city of some 160,000 i...

A concentrated bacterial culture supernatant from the hemolytic Moraxella bovis strain UQV 148NF was used to immunize mice and generate monoclonal antibodies (MAbs). One, MAb G3/D7, neutralized the hemolytic activity of M. bovis and recognized a 94-kDa protein by Western blot analysis in hemolytic M. bovis strains representing each of the different fimbrial serogroups. Exposure of corneal epith...

Carbon monoxide formation from heme compounds by bacteria was investigated to study microbial hemoprotein catabolism with reference to heme degradation by mammalian tissues. Hemolytic and nonhemolytic bacteria were incubated aerobically and anaerobically with the following substrates: erythrocytes, hemoglobin, myoglobin, cytochrome c, hematin, iron hematoporphyrin, copper hematoporphyrin, proto...

There is a significant risk of disease recurrence in patients with diarrhea-negative hemolyticuremic syndrome undergoing renal transplantation. Considering the low frequency of hemolyticuremic syndrome among adults with end-stage renal disease, only a few reports are available on the outcome of these patients after renal transplantation. It has been suggested, though not proven, that living rel...

Brucellosis is a worldwide zoonotic disease associated with hemolytic complications, including thrombotic microangiopathy (TMA) and hemolytic anemia. Autoimmune hemolytic anemia (AIHA) is a rare clinical presentation of this disease. In this report, we describe the cases of two patients with brucellosis who presented with Coombs-positive AIHA. We also include a review of the literature on the h...