Langerhans cell histiocytosis (LCH) merupakan salah satu penyakit terbanyak dari histiositosis dengan 2,0–5,4 kasus/100 juta populasi diseluruh dunia usia<15 tahun dan jarang terjadi pada dewasa. Penyakit ini bermanifestasi sebagai spektrum klinik gejala bervariasi mulai ringan, tersebar tubuh, bahkan bisa mengancam nyawa penderitanya. Klinisi ahli patologi dapat mengenali manifestasi klinis...

Fibreoptic broncho-alveolar lavage was used in four patients; the diagnosis of histiocytosis X had been established by lung biopsy in three and was suggested on clinical grounds in the remaining patient. Characteristic cells with an ultrastructural cytoplasmic marker (X body) were found in the washes of all four patients. In the patient without biopsy confirmation, the findings in the broncho-a...

Benign cephalic histiocytosis (BCH) is a rare non-Langerhans cell histiocytosis of unknown etiology. Clinically, lesions are characterized by small, red-to-yellow papules distributed mainly on the head, face, neck, and shoulders of infants and children. Histopathological specimens show massive histiocytic infiltration of the superficial dermis. Immunohistochemically, they are positive for CD68,...

Sea-blue histiocytosis is a rare disorder seen in patients with lipid metabolic or ceroid storage diseases. Sea-blue histiocytes are ceroid-laden macrophages detectable by May-Giemsa staining. We report a case of a 28-year-old woman diagnosed with Niemann-Pick disease at 2 or 3 years of age. To confirm this diagnosis, we examined her bone marrow, which revealed scattered foci containing aggrega...