Insulin resistance is associated with obesity and may be accompanied by left ventricular diastolic dysfunction and myocardial remodeling. Decreased insulin metabolic signaling and increased oxidative stress may promote these maladaptive changes. In this context, the beta-blocker nebivolol has been reported to improve insulin sensitivity, increase endothelial NO synthase activity, and reduce NAD...

preliminary studies revealed that urtica dioica has been known as a plant that decrease blood glucose. despite the importance of this plant in herbal medicine, relatively little research has been down on effects of this plant on islets yet. the objective of the current study was to evaluate the effect of dried urtica dioica leaf alcoholic and aqueous extracts on the number and the diameter of t...

Melanoma is extremely resistant to chemotherapy and the death rate is increasing hastily worldwide. Extracellular matrix promotes the migration and invasion of tumor cells through the production of matrix metalloproteinase (MMP)-2 and -9. Evidence has shown that natural dietary antioxidants are capable of inhibiting cancer cell growth. Our recent studies showed that hinokitiol, a natural bioact...

Preliminary studies revealed that Urtica dioica has been known as a plant that decrease blood glucose. Despite the importance of this plant in herbal medicine, relatively little research has been down on effects of this plant on islets yet. The objective of the current study was to evaluate the effect of dried urtica dioica leaf alcoholic and aqueous extracts on the number and the diameter of t...

A 10 week feeding trial was conducted to evaluate the potential effects of ginger powder (GP) and extract nanoparticles (GNPs) on growth parameters, digestive enzymes (lipase amylase) activities, blood hematology, biochemical indices, immune indices (interleukin 10, immunoglobulin M, nitric oxide, lysozymes), antioxidant activity, histological characteristics kidney, spleen, liver, intestine, r...

Background & Aim:Citrus paradisi Macfad (Rutaceae) seed extract (CPE) is used in folkloric medicine for the management of diabetes, blood deficiencies and as immune booster, which may require long term usage. This study aimed to evaluate the toxicity profile of ethanol seed extract of grapefruit in adult Wistar rats in order to determine its safety profile in whole org...

Chlorpyrifos is a most widely used organophosphate insecticide because of its cost effectiveness and degradable nature. However, this pesticide enters and contaminates the environment either by direct application, spray drifts or crop run off and shows adverse effect on the non-targeted organisms. Philosamia ricini (eri silkworm), one of the most exploited, domesticated and commercialized non m...

BACKGROUND Sida cordata, a member of Family Malvaceae is used in folk medicine for various ailments including liver diseases. In this study we investigated, its flavonoid constituents, in vitro antioxidant potential against different free radicals and hepatoprotection against carbon tetrachloride (CCl4)-induced liver damage in rat. METHODS Dried powder of S. cordata whole plant was extracted ...

BACKGROUND & OBJECTIVES Protecting myocardium from ischaemia-reperfusion (I-R) injury is important to reduce the complication of myocardial infarction (MI) and interventional revascularization procedures. In the present study, the cardioprotective potential of hydroalcoholic extract of Andrographis paniculata was evaluated against left anterior descending coronary artery (LADCA) ligation-induce...

BACKGROUND Alcohol-induced hyperlipidemia is positively correlated with cardiovascular diseases. Several herbal extracts have been reported to protect the cardiac injury and suppress the hyperlipidemia. However, the effect of ginger extracts on alcohol-induced hyperlipidemia and associated myocardial damage remains unclear. OBJECTIVE This study investigated the cardio-protective properties of...