نتایج جستجو برای: human granulocyte macrophage colony stimulating factor

تعداد نتایج: 2381015  

2014
Ikuko Nakamura Jun-ichi Oyama Hiroshi Komoda Aya Shiraki Yoshiko Sakamoto Isao Taguchi Atsushi Hiwatashi Aiko Komatsu Masayoshi Takeuchi Sho-ichi Yamagishi Teruo Inoue Koichi Node

BACKGROUND The purpose of this study was to elucidate the effects of glimepiride on the levels of biomarkers related to cardiovascular regulation in patients with type 2 diabetes mellitus. METHODS AND RESULTS Thirty-four patients with type 2 diabetes received glimepiride for 24 weeks. Significant decreases in the levels of glyceraldehyde-derived advanced glycation end products, (glycer-AGE: t...

2013
Gordon Wong Steven C. Clark Eliza Hall

A purified recombinant human granulocyte-macrophage colony stimulating factor (rH GM-CSF) was a powerful stimulator of mature human eosinophils and neutrophils. The purified rH GMCSF enhanced the cytotoxic activity of neutrophils and eosinophils against antibody-coated targets, stimulated phagocytosis of serum-opsonized yeast by both cell types in a dose-dependent manner, and stimulated neutrop...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1994
P N Pharr M Ogawa A Hofbauer G D Longmore

Whether the presence of specific receptors on the surface of developing cells is the cause or consequence of lineage restriction is not known. If activation of specific receptors is the driving event in differentiation, the premature expression of specific receptors would promote differentiation along that pathway. In this study pluripotent progenitors, obtained from blast cell colonies (pooled...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1986
J Y Chan D J Slamon S D Nimer D W Golde J C Gasson

Colony-stimulating factors (CSFs) are glycoproteins that stimulate the growth of hematopoietic progenitors and enhance the functional activity of mature effector cells. Human granulocyte/macrophage colony-stimulating factor (GM-CSF) is a 22-kDa glycoprotein that stimulates the growth of myeloid and erythroid progenitors in vitro and increases the responsiveness of neutrophils, monocytes, and eo...

Journal: :Blood 1995
C B Brown P Beaudry T D Laing S Shoemaker K Kaushansky

We have cloned, expressed, and partially purified a naturally occurring, truncated, soluble form of the human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha subunit to investigate its biochemical and biologic properties. The soluble receptor species lacks the transmembrane and cytoplasmic domains that are presumably removed from the intact receptor cDNA by a mechanism ...

Journal: :American journal of respiratory cell and molecular biology 2002
Shahryar Saba Grace Soong Steven Greenberg Alice Prince

Airway epithelial cells provide an immediate response to bacterial pathogens by producing chemokines and cytokines that recruit polymorphonuclear leukocytes (PMNs) to the site of infection. This response is excessive in patients with cystic fibrosis (CF) who have bacterial contamination of their airways. We postulated that CF airway pathogens, in activating nuclear factor-kappaB-dependent gene ...

Journal: :iranian journal of basic medical sciences 0
manouchehr safari research center of nervous system stem cells, department of anatomy, semnan university of medical sciences, semnan, iran behnaz jafari research center of nervous system stem cells, department of anatomy, semnan university of medical sciences, semnan, iran sam zarbakhsh research center of nervous system stem cells, department of anatomy, semnan university of medical sciences, semnan, iran hamidreza sameni research center of nervous system stem cells, department of anatomy, semnan university of medical sciences, semnan, iran abbas ali vafaei department of physiology, semnan university of medical sciences, semnan, iran nasrin khan mohammadi research center of nervous system stem cells, department of anatomy, semnan university of medical sciences, semnan, iran

objective(s): granulocyte-colony stimulating factor (g-csf) is used in clinical practice for the treatment of neutropenia and to stimulate generation of hematopoietic stem cells in bone marrow donors. in the present study, the ability of g-csf in mobilizing exogenous bone marrow stem cells (bmscs) from peripheral blood into the brain was tested. we for the first time injected a small amount of ...

Journal: :iranian journal of veterinary research 2016
m.h. kang h.m. park

two dogs with generalized seizures were evaluated. the dogs were diagnosed with traumatic intracranial hemorrhages based on the history, neurological examinations, and magnetic resonance imaging (mri) of the brain. treatment was started with oxygen, prednisolone and anticonvulsant agents. no further seizure activity was observed after treatment in both dogs, however cushing reflex was detected ...

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