BACKGROUND Type 2 T-helper cells (Th2) are involved in the regulation of the humoral immune response against antigens and allergens and directly affect which isotype will be produced. The mechanism that regulates antigen-specific IgE secretion and immune deviation is still not known. OBJECTIVES To delineate mechanisms behind antigen-specific IgE secretion we have used in vitro immunization an...

BACKGROUND Developing vaccines for the prevention of human infection by H5N1 influenza viruses is an urgent task. DNA vaccines are a novel alternative to conventional vaccines and should contribute to the prophylaxis of emerging H5N1 virus. In this study, we assessed whether a single immunization with plasmid DNA expressing H5N1 hemagglutinin (HA) could provide early protection against lethal c...

Survivin, a 16.5 kDa tumor associated antigen, is the smallest member of the inhibitor of apoptosis family that is abundantly expressed during development but essentially absent in normal adult tissues. Interestingly, survivin expression is up-regulated in virtually all types of cancers studied, as well as in vascular endothelial cells during tumor associated angiogenesis. Survivin links apopto...

introduction: antifertility effects of naturally occuring antisperm antibody (asa) in infertile couples and studies on experimental immunization of various animals with sperm antigens represent asa as an immunocontraceptive target. the effects of different factors on sperm immunogenecity and asa production have been studied and different results have been reported. in this study, whole sperm im...

introduction: neonatal tetanus is a highly fatal disease that can be prevented by immunization and improvement in obstetric practices. the aim of the present study was to assess the characteristics of cases of neonatal tetanus in two large tertiary hospitals (ghaem and imam reza hospitals) of mashhad -north east of iran between 1984- 2001. methods: all cases whose epidemiological and clinical c...

Development of vaccine for contraception is an exciting proposition that could provide a valuable alternative to the presently available methods for birth control. Various targets such as gonadotropin releasing hormone (GnRH), follicle stimulating hormone (FSH), leutinizing hormone (LH), zona pellucida (ZP) antigens, sperm antigens, and human chorionic gonadotropin (hCG) are being explored for ...

Objective(s): Many types of human papillomaviruses (HPVs) have been identified, with some leading to cancer and others to skin lesions such as anogenital warts. Studies have demonstrated an association between oncogenic HPV and cervical cancer and many researchers have focused on therapeutic vaccines development. At present, the modulatory effect of opioids on the innate and acquired immune sys...

Vaccination considered as one of the most cost-effective health interventions worldwide  through prevention and control of many serious childhood diseases (1). It is estimated  global coverage of  Dose 3 of Diphtheria, Tetanus, and Pertussis (DTP3)among children one year old has been 86% in 2014 (by range from 77% to 96%  in African Region and Western Pacific Region; respectively) (2). Globally...

not beginning or completing the vaccination schedule as recommended in the expanded programme on immunization is one of the major reasons for low immunization coverage. it should be studied in detail for remedial action, if the objectives of the epi in iran are to be achieved as stated. generally, lack of knowledge, lack of motivation and obstacles ore the basic categorical reasons for low cove...