In rats that were allowed to eat the placentae after parturition concentrations of serum prolactin were elevated on Day 1 but concentrations of serum progesterone were depressed on Days 6 and 8 post partum when compared to those of rats prevented from eating the placentae. In rats treated with PMSG to induce superovulation serum prolactin and progesterone values were significantly (P < 0.05) el...

Broken cell preparations of rat and human placentas contain an inner (tyrosyl)-ring iodothyronine deiodinase enzyme with greatest activity when the substrate is 3,5,3'-triiodothyronine (T3). This report describes the deiodination of T3 in the intact placenta and the effect of sodium iopanoate (IA) and propylthiouracil (PTU) on T3 deiodination. Under nembutal anesthesia, the placenta of 60-65-d-...

placenta increta, a rare complication of pregnancy, is associated with significant postpartum hemorrhage often requiring emergency hysterectomy. we report a case of conservative management, with a combination of parenteral methotrexate, serial ultrasound and β-hcg assessment. serum β-hcg levels were undetectable after 8 weeks of therapy. a scan at 6 months showed complete involution of the uter...

Introduction: Mesenchymal stem cells can be isolated from adult tissues, such as the adipose tissue, or other sources. Among all these sources, adipose tissue because of easy access, and placenta due to its immunomodulatory properties, in addition to another useful properties, were attracted more attention to themselves. Isolation and comparing these two different sources can help us for acces...

Abnormal fetal growth, which is associated with both perinatal morbidity as well as metabolic diseases in adulthood, is an important clinical problem affecting as many as 15% of all pregnancies. However, to this date, there is no specific treatment of this condition. Fetal growth is intimately linked to the nutrient transport functions of the placenta and placental amino acid transporter activi...

The influence of methotrexate (MIX), dibutyryl cyclic AMP, and actinomycin D on production of human chorionic gonadotropin (HCG) in normal first trimester human placenta) organ cultures was compared. Actinomycin D (10"" to 10~*M) elevated HCG production by as much as 3.5-fold in normal placenta, and a 2-fold increase in HCG levels was obtained by treatment with dibutyryl cyclic AMP (1 m\i) and ...

BACKGROUND SERPINE2, one of the potent serpins belonging to the plasminogen activator (PA) system, is involved in the tissue remodeling. We previously demonstrated the expression patterns of Serpine2 in the mouse placenta and uterus, indicating that Serpine2 is a major PA inhibitor in the placenta and uterus during the estrous cycle, pregnancy, and lactation. In this study, we further investiga...

The placenta plays a key role in maintaining healthy pregnancy. In order to improve drug safety during pregnancy, it is therefore relevant understand which extent and at rate drugs are transferred across the how pharmaceuticals may affect placental function. Translational predictive pharmacology studies based on human tissues cells becoming increasingly important characterizing effects disposit...