Artemisinin and its derivatives were considered to exert a broad spectrum of anti-cancer activities, and they induced significant anti-cancer effects in tumor cells. Artemisinin and its derivatives could be absorbed quickly, and they were widely distributed, selectively killing tumor cells. Since low concentrations of artesunate primarily depended on oncosis to induce cell death in tumor cells,...

Nano hydroxyapatite and Silicon-substituted hydroxyapatite nanocomposites with various amount of Si contents (0, 2, 4 and 6 mole % as named as HS0, HS2, HS4 and HS6) were prepared via in situ hybridization method and were analyzed by XRD, FTIR, SEM and AFM techniques. Size distribution of the products demonstrated that hydroxyapatite particles size was between 2 and 53.5 nm with further mean si...

The purpose of this study is to investigate the interaction of Etofylline as an established drug for asthma remedy, with the major transport protein in human blood circulation, the human serum albumin (HSA). In this respect, the fluorescence and circular dichroism (CD) spectroscopy techniques, along with the molecular docking and molecular dynamics simulation methods were employed. Analysis of ...

Azoospermia is one of the challenging disorders affecting couples who are afflicted with infertility. Human testisderivedcells (hTCs) are suitable candidates for the initiation of in-vitro spermatogenesis for these types of patients.The current study aimed to assess the proliferation of hTCs through the cell culture on the three-dimensional (3D) porousscaffolds. Cells harveste...

Today, human effects due to industrial development and population increase caused water ecosystems be polluted by various pollutant such as heavy metals. Serum biochemical parameters are widely used in blood analysis these suitable indicators for monitoring physiological changes fish. Hence, the aim of present study waterborne copper on serum glucose, total protein, albumin triglyceride levels ...

Background: Progress in the field of biology and biochemistry has led to the discovery of numerous bioactive peptides and proteins in the last few decades. Delivery of therapeutic proteins/peptides has received a considerable amount of attention in recent years. Methods: In this study, a two-step desolvation method was used to produce biodegradable hydrophilic gelatin nanoparticles (GNP) as a d...