ObjectiveMetabolomic profiling of seminal plasma has been suggested as a possible approach for fast and non-invasive male infertility evaluation diagnosis. However, metabolomics profiles in normozoospermic men have not thoroughly investigated, the influence ejaculation-abstinence described.To provide interim reference values find associations between human length period men.Study designSemen sa...

Vitronectin plays a role in the regulation of complement and thrombin activities and in cell surface proteolysis. Vitronectin is also an intrinsic protein of human spermatozoa. Vitronectin message has been detected in whole testis poly-A mRNA and localized by in-situ reverse transcription-polymerase chain reaction to spermatocytes. The proportion of spermatozoa that express vitronectin increase...

Previous studies on the clastogenic effects of mutagens on human sperm chromosomes were reviewed. A marked increase of structural chromosome aberrations (SCAs) has been reported in the spermatozoa irradiated in vitro with five kinds of ionizing radiation (137Cs gamma-, 60Co gamma-, X-, and 3H beta-rays and 252Cf neutrons). The micronucleus (MN) test with hybrid two-cell embryos generated from h...

BACKGROUND The mechanism of action of levonorgestrel (LNG) as emergency contraception (EC) remains a subject of debate and its effect on sperm function has been only partially explained. The aim of this study was to assess whether LNG at a similar dose to those found in serum following oral intake for EC could affect spermatozoa when exposed to human fallopian tubes in vitro. METHODS Fifteen ...

introduction: cryopreservation of single human spermatozoa is a new technique designed to improve the management of male infertility, it was first introduced in 1997 and was reported by others latter. the aim of this research was to evaluate the efficiency of this method in preserving either ejaculated or surgically retrieved spermatozoae. materials and methods: spermatozoae were obtained from ...

In mammals, Ca2+ and HCO3- ions play a critical role in the regulation of sperm function, most likely by regulation of cAMP levels. Mammalian germ cells contain a soluble adenylyl cyclase (sAC) with properties distinct from the well characterized membrane-bound enzymes Here we investigated whether the cyclase expressed in mature spermatozoa has the properties of sAC and whether it is regulated ...