OBJECTIVE To evaluate the role of phenobarbitone in the management of unconjugated hyperbilirubinemia during first two weeks of life in preterm neonates. DESIGN Meta-analysis. METHODS A study was eligible for inclusion in the metaanalysis if it randomized preterm neonates into control and treatment groups. Standard search strategy of the Cochrane Neonatal Review Group was used. For categori...

BACKGROUND Several studies suggest a protective role of bilirubin against oxidative damage during the neonatal period. ADA1*2 allele has been found associated with higher bilirubin levels in newborns and with a protective action against bronchial asthma. Thus the relation between ADA1 and asthma could be mediated by events occurring during the early extrauterine life. Moreover the increased pre...

background: phototherapy is believed to be a safe method for the management of hyperbilirubinemia. however, there are some controversial issues regarding the genotoxic effects of phototherapy on dna. the aim of this study was to investigate morphologically both phototherapy-induced dna double-strand breaks (dsbs) and apoptosis in lymphocytes derived from jaundiced and non-jaundiced neonates. me...

Hyperbilirubinemia is a common and in most cases benign clinical condition in neonates. Phototherapy is used for management of neonatal hyperbilirubinemia[1]. Phototherapy may lead to complications including skin rash, diarrhea, hyperthermia, chills, dehydration, DNA damage to lymphocytes, retinal degeneration, bronze baby syndrome especially in cholestatic jaundice and PDA opening in LBWs and ...

Abstract Background Blue light phototherapy used extensively in the management of hyperbilirubinemia has many side effects like dry eyes, blurring, headache, and altered circadian rhythm. Healthcare providers working around are unduly exposed to these effects. Altered rhythm results disruption sleep-wake cycle affecting healthcare particularly during night shift. The constant glare blue interru...

Abstract Background Neonatal jaundice, also known as hyperbilirubinemia in term and preterm infants, is treated with phototherapy when bilirubin results exceed gestational age- age-specific medical decision levels (MDL) to prevent kernicterus bilirubin-induced neurological damage. During phototherapy, unconjugated converted water-soluble isomers that are excreted the urine. Presently, electroni...

BACKGROUND Phototherapy is believed to be a safe method for the management of hyperbilirubinemia. However, there are some controversial issues regarding the genotoxic effects of phototherapy on DNA. The aim of this study was to investigate morphologically both phototherapy-induced DNA double-strand breaks (DSBs) and apoptosis in lymphocytes derived from jaundiced and non-jaundiced neonates. M...

Light therapy, also called phototherapy, exposes infants with jaundice [5], a yellowing of the skin and eyes, to artificial or natural light to break down the buildup of bilirubin pigment in the blood. Bilirubin is an orange to red pigment produced when red blood cells break down, which causes infants to turn into a yellowish color. Small amounts of bilirubin in the blood are normal, but when t...

Kernicterus and neurologic sequelae caused by severe neonatal hyperbilirubinemia are preventable conditions. A structured and practical approach to the identification and care of infants with jaundice can facilitate prevention, thus decreasing rates of morbidity and mortality. Primary prevention includes ensuring adequate feeding, with breastfed infants having eight to 12 feedings per 24 hours....

conclusions our study showed severe neonate indirect hyperbilirubinemia is still prevalence in fars province and ethnic and cultural background of the mothers was more effective than school education in preventing hyperbilirubinemia complication. patients and methods all infants less than 28 days referred due to severe indirect hyperbilirubinemia were included. complete history, physical examin...