flammation drugs (NSAIDs) and it is clinically the first choice among its own class, 2-arylpropionic acids, due to its low incidence of unwanted effects. It contains a chiral center adjacent to the carboxyl group and thus existed as ( ) R and ( ) S enantiomers. Ibuprofen was originally marketed as racemate and later in 1994 dexibuprofen was brought into the market in Austria and Switzerland bas...

Ibuprofen is a well established analgesic, anti-inflammatory and antipyretic NSAID. In three double-blind, multicentre trials in postoperative adult patients (n = 185-406), intravenous ibuprofen 800 mg once every 6 hours, as an adjunct to morphine, significantly reduced the consumption of morphine compared with placebo, as an adjunct to morphine, in two of the three trials (primary endpoint in ...

BACKGROUND Patent ductus arteriosus (PDA) is a common cause of morbidity. The aim of this study was to compare the efficacy of oral Acetaminophen and oral Ibuprofen for the closure of patent ductus arteriosus (PDA) in preterm infants. OBJECTIVES This study demonstrated that, there was no significant difference between treatment of PDA with either oral Acetaminophen or oral Ibuprofen in preter...

BACKGROUND Severe pulmonary hypertension may following ibuprofen administration for ductal closure. CASE CHARACTERISTICS An extremely preterm infant who developed severe pulmonary hypertension unresponsive to inhaled nitric oxide after ibuprofen administration. OUTCOME Pulmonary hypertension reversed after the administration of oral sildenafil, but the infant died due to complications relat...

The esterification of rac-ibuprofen and rac-ketoprofen with glycerol catalyzed the commercial biocatalyst Novozym® 435 was investigated at 45 °C various profen: molar ratios using 2-propanol as co-solvent in a batch type reaction. conversion reached 46%, an enantiomeric excess towards S-enantiomer 42%. When 1:4 ibuprofen:glycerol ratio assayed, 75% R-ibuprofen reacted monoglyceride 99% selectiv...

The aim of the present study was to analyze the changes of plasma and urinary prostaglandin E2 (PGE2) levels in preterm infants with symptomatic patent ductus arteriosus (sPDA) treated with oral ibuprofen and acetaminophen. A total of 87 preterm infants with sPDA admitted to the Neonatal Ward of the Affiliated Xuzhou Hospital of Medical College of Southeast University from October, 2012 to June...

Hirschsprung Disease (HSCR) is a potentially deadly birth defect characterized by the absence of the enteric nervous system (ENS) in distal bowel. Although HSCR has clear genetic causes, no HSCR-associated mutation is 100% penetrant, suggesting gene-gene and gene-environment interactions determine HSCR occurrence. To test the hypothesis that certain medicines might alter HSCR risk we treated ze...

Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to cause gastric mucosal damage as a side effect. Acetaminophen, widely used as an analgesic and antipyretic drug, has gastroprotective effects against gastric lesions induced by absolute ethanol and certain NSAIDs. However, the mechanisms that underlie the gastroprotective effects of acetaminophen have not yet been clarified. In the prese...