Investigation of turbulency on the rate of induced liquid circulation, gas hold-up, mixing time and overall gas–liquid volumetric oxygen mass transfer coefficient. The various types of surfactants (containing Brij58, TritonX-405, Tween40, HCTBr) with various concentrations of 1-5 ppm were examined on the operational characteristics of the reactor. In surfactant solutions (in comparison with pur...

We describe the characterization of a chip-based platform (3(D)-KITChip) for the three-dimensional cultivation of cells under perfusion conditions via magnetic resonance imaging (MRI). Besides the chip, the microfluidic system is comprised of a bioreactor housing, a medium supply, a pump for generating active flow conditions as well as a gas mixing station. The closed circulation loop is ideall...

We have developed an integrated array of microbioreactors, with 100 microL working volume, comprising a peristaltic oxygenating mixer and microfluidic injectors. These integrated devices were fabricated in a single chip and can provide a high oxygen transfer rate (k(L)a approximately 0.1 s(-1)) without introducing bubbles, and closed loop control over dissolved oxygen and pH (+/-0.1). The syste...

OBJECTIVE In this study, we describe a novel bioreactor system to deliver controlled stretch protocols to bioengineered heart muscle (BEHM) constructs. Our primary objective was to evaluate the effect of mechanical stretch on the contractile properties of three-dimensional cardiac constructs in vitro. METHODS BEHMs were formed by culturing primary neonatal cardiac myocytes in a fibrin gel usi...

The research and development of extracorporeal bioartificial liver is gaining pace in recent years with the introduction of a myriad of optimally designed bioreactors with the ability to maintain long-term viability and liver-specific functions of hepatocytes. The design considerations for bioartificial liver are not trivial; it needs to consider factors such as the types of cell to be cultured...

The development of energy-efficient solutions for large-scale fermenters demands a deep and comprehensive understanding hydrodynamic heat mass transfer processes. Despite wide variety research dedicated to measurements intensity in bubble flows, this subject faces new challenges due the topical innovative bioreactor designs. In order understand fluid dynamics gas–liquid medium, researchers need...