the effect of physiological concentrations of caffeine (purified from persian tea) on adenosine deaminase (ada) activity at physiological and pathological concentrations of adenosine (as substrate) in 50 mm tris-hcl buffer (ph 7.3) at 37°c was investigated, using uv-vis spectroscopy. ada exhibited a bi-phasic activity behavior and both phases showed positive cooperativities indicating adenosine...

interaction between urokinase-type plasminogen activator (upa) and its receptor (upar) plays an important role in the progression of numerous cancer types including breast cancer by promoting tumor initiating,  proliferation,  invasion  and  metastasis.  hence,  disruption  of  this  interaction  inhibits  their downstream cascades and subsequently tumor growth. for this, we created two series ...

to evaluate the effect of metarhizium anisopliae and trichoderma harzianum on root knot nematode (meloidogyne javanica) in tomato, experiments was performed under controlled as well as greenhouse conditions. volatile and non-volatile tests showed that there is no inhibitory effect against every one of each biocontrol agents. on the larval mortality and inhibition of egg hatching, a laboratory t...

due to the high antagonistic activity of bacterium, bacillus subtilis (ehrenberg) cohn, three isolates (b.s.ham, 204 and 202) were selected and their efficacy were studied in control of sugar beetdamping–off caused by rhizoctonia solani , in  in vitro and in vivo conditions.  in dual culture on pda, all isolates of b.subtilis inhibited mycelial growth of r.solani.  significantly, volatile metab...

lncrnas (long non-coding rnas) are responsible to control the degradation process, rna stability, orchestration, inhibition, transcription and histone modification etc. these rnas have been termed as the key agents of several mechanisms such as development, organogenesis and regeneration of damaged tissues etc. they interact with a number of partner molecules either protein, rnas or dnas and co...

MicroRNAs (miRNAs) involved in regulation of the genes. The CCAAT/enhancer-binding protein-α (CEBPα) is a crucial transcription factor for normal hematopoiesis and cell cycle that frequently disrupted in human acute myeloid leukemia (AML). The miR-182 up-regulation in several malignant diseases such as AML was reported, in the other hand bioinformatics analysis revealed CEBPα targeted by miR-18...

Cyclooxygenase-2 (COX-2) has a pivotal role in the pathogenesis of the lung cancer. It is known that COX-2 negatively regulates the activity of a number of tumor suppressors, including p53. Consequently, inhibition of COX-2 signaling is anticipated to be a promising approach to stabilize p53 functionality. In this regard, we investigated the effect of COX-2 signaling blockade on p53 and COX-2 e...

One way in which an organism controls its biosynthetic pathways is by feedback inhibition. This control adjusts the rate of production of the end products of pathways, such as amino acids and nucleotides, to the rate of synthesis of macromolecules, such as proteins and nucleic acids. Control is imposed by the end product itself in a simple and rapid manner: the end product stops production of m...

The current study tested 2 models of inhibition in 45 children with language impairment and 45 children with normally developing language; children were aged 7 to 12 years. Of interest was whether a model of inhibition as a mental-control process (i.e., executive function) or as a mental resource would more accurately reflect the relations among mental-attentional (M) capacity, inhibition, upda...