“It is not acceptable that millions of children miss their vaccines every year. We have a safe and highly effective vaccine to stop the spread of measles and save lives,” said Dr. Jean-Marie Okwo-Bele, Director of WHO’s Department of Immunization, Vaccines and Biologicals. “This year, the Region of the Americas was declared free of measles – proof that elimination is possible. Now, we must stop...

This is a seminar talk of February 13, 2008. 1. Wick’s theorem for R-valued normal vectors The following is known as Wick’s theorem. Theorem A (Wick [9]). If (X1, . . . , X2n) is multivariate normal with mean zero, then E(X1X2 . . . X2n) = ∑ V ∏ {j,k}∈V E(XjXk), where the sum is taken over all pair partitions V of {1, 2, . . . , 2n}.1 For example, E(X1X2X3X4) = E(X1X2)E(X3X4)+E(X1X3)E(X2X4)+E(X...

(mAbs), are complex protein molecules produced from mammalian tissue culture cells through recombinant DNA technology. As a result of naturally-occurring molecular heterogeneity as well as chemical and enzymatic modifications during manufacture, process, and storage, there are many product quality attributes (PQAs) presenting in therapeutic proteins. These PQAs can potentially include: product-...

roblast growth factor receptor 2 transcripts mediates cell-type-specific splicing by approximating intronic control elements. Mol Cell Biol 23:9327–9337, 2003 Bauters C, Six I, Meurice T, Van Belle E: Growth factors and endothelial dysfunction. Drugs 59:11–15, 1999 Di Paola R, Frittitta L, Miscio G, et al: A variation in 30 UTR of hPTP1B increases specific gene expression and associates with in...

Much of molluscan behaviour is stereotyped and therefore more amenable to analysis than the highly complex and variable behaviour of phylogenetically more advanced animals. Several types of molluscan behaviour have been studied, varying from sequential swimming and digging patterns (Dorsett, Willows & Hoyle, 1969; Mellon, 1969; Trueman, 1967) to simple withdrawal responses (Mellon, 1965; Peretz...

Using the Single Electron Capacitance Spectroscopy, we study the energies required to add electrons to a quantum dot in a broad range of electron occupancy N. Following evolution of these energies as a function of magnetic field, we unveil the nature of the states occupied by electrons. For small N electrons fill states, which resemble oneelectron energy levels in a parabolic confinement. When ...

Every few weeks I read another journalist’s jab at the value and qttarttity of scientific journals. When discussing the ever-expanding literature, reporters of the popular press frequently indulge in supertlcial analyses that distort reality, whether through misunderstanding or exaggeration. Nancy Jeffrey revealed profound misunderstanding in “Mollusks, Semiotics and Dermatology: Narrow Scholar...

93 perhaps somewhat less gifted, the doctor, now as then, finds himself accused of few virtues and provided gratis with an exhaustive catalog of all those things wherein he has been remiss. But after all, grumbler as well as genius must have its butt, and from Moliere to Shaw the less and the lesser lights have found delight in seeking vulnerable points through which a jab could advantageously ...

A ”Kallen-Lehman” approach to Ising model, inspired by quantum field theory a la Regge, is proposed. The analogy with the Kallen-Lehman representation leads to a formula for the free-energy of the 3D model with few free parameters which could be matched with the numerical data. The possible application of this scheme to the spin glass case is shortly discussed. Keyword: Regge theory, spin glass...