A 37-year-old male case was admitted with goiter. Ultrasonography of thyroid showed a 5 cm cystic nodule in the left lobe with a 1.5 cm solid component. Fine needle aspiration biopsy revealed atypia of undetermined significance or follicular lesion. The patient was operated on. The pathological diagnosis was reported as papillary thyroid carcinoma. The immunohistochemical examination showed mul...

Smoking is a risk factor for disease that contributes the most to lung and respiratory diseases. Lung related with cigarette smoke can be classified as COPD (Chronic Obstructive Pulmonary Disease) several types of interstitial such pulmonary langerhans cell histiocytosis, bronchiolitis, desquamative pneumonitis fibrosing disease. This literature review aims shed light not only causes inflammati...

Dendritic cells migrate from the skin to the draining lymph nodes. They transport immunogenic MHC-peptide complexes, present them to Ag-specific T cells in the T areas, and thus generate immunity. Migrating dendritic cells encounter physical obstacles, such as basement membranes and collagen meshwork. Prior work has revealed that matrix metalloproteinase-9 (MMP-9) contributes to mouse Langerhan...

BACKGROUNDS Basal cell carcinoma affects areas of the body that have been exposed to the sun, and this disorder has different clinical and histopathologic presentations. Some of these forms have a higher potential of local aggressiveness, while others have a lower potential. Langerhans cells actively participate in the skin immune system. OBJECTIVES To quantitatively evaluate the number of La...

Effects of elephant garlic (Allium ampeloprasum) volatile oil (GVO) and trichothecene (T2) toxin were studied in Swiss albino mice. The animals were 1) topically applied GVO, 2) topically applied T-2 toxin, 3) topically applied GVO followed by T-2 toxin (GVO/T-2), and 4) T-2 toxin application followed by GVO (T-2/GVO) on the right footpad. All animals were observed by Langerhans cell enumeratio...

This article discusses the potential of droplet digital polymerase chain reaction (PCR) for diagnostic detection and monitoring allelic load BRAF V600E mutation in circulating cell-free DNA myeloid progenitor cell population bone marrow patients with Langerhans histiocytosis (LCH). Droplet PCR may serve as a useful tool minimal residual disease improve our understanding pathogenesis cells histi...

Langerhans cell sarcoma, a neoplastic proliferation of Langerhans cells with malignant cytologic features, is a very rare disease. Only a few cases have been documented in the English-language literature. Special methods, like immunohistochemistry and/or ultrastructural examination, are indispensable for appropriate diagnosis. Correct diagnosis is difficult. In fact, the disease is often misdia...

Langerhans cell histiocytosis (LCH) is a clonal disorder believed to be derivedfrom cells of the dendritic system. Fascin, a 55-kd actin-bundling protein, represents a highly selective marker for dendritic cells of lymphoid tissues and peripheral blood and is involved in the formation of dendritic processes in maturing epidermal Langerhans cells. Since lesional cells of LCH may represent Langer...