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Background: Regional anaesthesia techniques are now being preferred over General in patients with major medical problems and those at high risk for GA. Thoracic segmental spinal has recently gained popularity because of its safety efficacy procedures like laparoscopic cholecystectomy, breast surgeries etc. Methods: A comparative study involving 50 ASA grade I & II both genders age group 25-...

This work aimed to develop a subcutaneous implant for prolonged delivery of LEVO treat hypothyroidism. could overcome challenges with patient compliance and co-administration improve treatment this condition. For purpose, implants were produced by solvent casting mixtures poly(caprolactone) (PCL), poly(ethylene glycol) (PEG) sodium. These contained PCL differing molecular weight, PEG different ...

BACKGROUND Due to potential proarrhythmic side-effects levo-alpha-Acetylmethadol (LAAM) is currently not available in EU countries as maintenance drug in the treatment of opiate addiction. However, recent studies and meta-analyses underline the clinical advantages of LAAM with respect to the reduction of heroin use. Thus a reappraisal of LAAM has been demanded. The aim of the present study was ...

Tetrahydroprotoberberines (THPBs) are isoquinoline alkaloids isolated from the Chinese herb Corydalis yanhusuo. In the present study, we performed competitive binding assays to examine the binding of l-THBr to neurotransmitter receptors known to be involved in sedation, hypnosis and anxiety. Our results show that l-THBr does not interact with GABAergic receptors but has binding affinities for d...

Levo-tetrahydropalmatine (l-THP) is an alkaloid found in many traditional Chinese herbal preparations and has a unique pharmacological profile that includes dopamine receptor antagonism. Previously we demonstrated that l-THP attenuates fixed-ratio (FR) cocaine self-administration (SA) and cocaine-induced reinstatement in rats at doses that do not alter food-reinforced responding. This study exa...