Objective: Investigation of in vitro/in vivo behaviour of fast-dissolving tablets containing solid dispersions of oxcarbazepine is the focus of the present research work. Methods: The effect of various hydrophilic polymers on the aqueous solubility of oxcarbazepine was studied. Polyethylene glycol 6000 carrier was selected and solid dispersions were prepared by various methods. A total of nine ...

This paper contains several results concerning the role of symmetries and singularities in the mathematical formulation of many physical systems. We concentrate in systems which find their mathematical model on a symplectic or Poisson manifold and we present old and new results from a global perspective.

This paper is devoted to bilevel optimization, a branch of mathematical programming of both practical and theoretical interest. Starting with a simple example, we proceed towards a general formulation. We then present fields of application, focus on solution approaches, and make the connection with MPECs (Mathematical Programs with Equilibrium Constraints).

Time-dependent Vehicle Routing Problem is one of the most applicable but least-studied variants of routing and scheduling problems. In this paper, a novel mathematical formulation of time-dependent vehicle routing problems with heterogeneous fleet, hard time widows and multiple depots, is proposed. To deal with the traffic congestions, we also considered that the vehicles are not forced to come...

Centralizing and using proper transportation facilities cut down costs and traffic. Hub facilities concentrate on flows to cause economic advantage of scale and multimodal transportation helps use the advantage of another transporter. A distinctive feature of this paper is proposing a new mathematical formulation for a three-stage p-hub location routing problem with simultaneous pick-ups and de...

The aim of this study was to assess the effects of processing parameters on the release of solid dispersion formulation from a fast dissolving tablet dosage form. Graphical and mathematical analysis such as the response surface methodology (RSM) and multiple response optimizations utilizing the polynomial equation were used to search for the optimal formulation and to quantify the effect of eac...

Abstract Location-Routing problems involve locating a number of facilities among candidate sites and establishing delivery routes to a set of users in such a way that the total system cost is minimized. A special case of these problems is Hamiltonian p Median Problem (HpMP). In attempting to solve this problem, numerous mathematical formulations have been proposed. Most of them have in common t...

This paper presents a continuous-time mathematical formulation for freshwater and wastewater minimisation in multipurpose batch plants with and without a central reusable water storage facility. The minimisation of wastewater is achieved through the exploitation of recycle and reuse opportunities. A superstructure that entails all the possible recycle and reuse possibilities is used as the basi...

This paper presents a mathematical deterministic adaptive distance protection formulation for UPFC compensated transmission lines. The proposed formulation is developed using a phase component approach and considers and compensates for various UPFC operation conditions and non-zero fault resistances. The proposed methodology is completely adaptive and independent of system characteristics (such...

This paper deals with the mathematical modeling and performance optimization for the Digesting system of a Paper Plant using Genetic Algorithm. The Digesting system of a Paper Plant has four main subsystems, arranged in series and parallel. Considering exponential distribution for the probable failures and repairs, the mathematical formulation of the problem is done using probabilistic approach...