Studies were performed to examine the extent to which mechanical stimuli mediate control of angiogenesis in bladder cells both in vitro and in vivo. Differential gene expression between control nonstretched and cyclically stretched bladder smooth muscle cells was assessed using oligonucleotide microarrays and pathway analysis by the web tool Fast Assignment and Transference of Information (Fati...

BACKGROUND Alzheimer's disease (AD) is characterized by a neurodegenerative progression that alters cognition. On a phenotypical level, cognition is evaluated by means of the MiniMental State Examination (MMSE) and the post-mortem examination of Neurofibrillary Tangle count (NFT) helps to confirm an AD diagnostic. The MMSE evaluates different aspects of cognition including orientation, short-te...

Yang R, Amir J, Liu H, Chaqour B. Mechanical strain activates a program of genes functionally involved in paracrine signaling of angiogenesis. Physiol Genomics 36: 1–14, 2008. First published October 14, 2008; doi:10.1152/physiolgenomics.90291.2008.—Studies were performed to examine the extent to which mechanical stimuli mediate control of angiogenesis in bladder cells both in vitro and in vivo...

RUSH/SMARCA3 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A, member 3) is capable of sequence-selective DNA binding and ATP-dependent DNA unwinding. In rabbit uterine epithelial cells, RUSH-1alpha (113 kDa) is the progesterone-dependent splice variant and RUSH-1beta (95 kDa) is the oestrogen-dependent splice variant. Rabbit RUSH/SMARCA3 mRNA is primarily r...

Steroids regulate alternative splicing of RUSH/SMARCA3. The full-length, progesterone-dependent α isoform and the 3′-truncated, estrogen-dependent β isoform have identical DBDs, NLSs and RING fingers. Transcription of RUSH/SMARCA3 is mediated by a bipartite progesterone receptor halfsite/overlapping Y-box combination (-38/-26), where progesterone activation is attenuated by NF-Y binding. Regula...

All affinely covariant convex-body-valued valuations on the Sobolev space W (R) are completely classified. It is shown that there is a unique such valuation for Blaschke addition. This valuation turns out to be the operator which associates with each function f ∈W (R) the unit ball of its optimal Sobolev norm. 2000 AMS subject classification: 46B20 (46E35, 52A21,52B45) Let ‖ ·‖ denote a norm on...

INTRODUCTION MicroRNAs (miRNAs) down-regulate their target genes. The intronic miR-140, present in the WW domain containing E3 ubiquitin protein ligase 2 (WWP2) gene, decreases the expression of genes that play detrimental roles in osteoarthritis (OA). As the expression level of miR-140 is significantly decreased in human OA chondrocytes, we investigated its regulation in those cells. METHODS...

Bu ara?t?rman?n temel amac?, Türkiye’de ya?ayan Suriyelilerin kalma, ba?ka bir ülkeye gitme veya ülkelerine dönme e?ilimlerini etkileyen faktörleri ortaya koymakt?r. Ara?t?rma Gaziantep ve ?zmir kent merkezlerinde nitel tasar?mla gerçekle?tirilmi?tir. Gaziantep’te 30, ?zmir’de 27 ki?i olmak üzere 57 yar? yap?land?r?lm?? görü?menin yan? s?ra 2 1 3 odak grup görü?mesi yap?lm??t?r. Verilerin anali...

Most patients with familial pulmonary arterial hypertension (FPAH) carry mutations in the bone morphogenic protein receptor 2 gene (BMPR2). Yet carriers have only a 20% risk of disease, suggesting that other factors influence penetrance. Thrombospondin-1 (TSP1) regulates activation of TGF-β and inhibits endothelial and smooth muscle cell proliferation, pathways coincidentally altered in pulmona...