We investigated the capacity of intrathecal arachidonyl-2'-chloroethylamide (ACEA), a cannabinoid-1 receptor (CB1R) agonist, to inhibit referred hyperalgesia and increased bladder contractility resulting from acute acrolein-induced cystitis in rats. 24 female rats were divided into 4 groups: 1) intrathecal vehicle/intravesical saline; 2) intrathecal vehicle/intravesical acrolein; 3) intrathecal...

This paper presents an uncertainty analysis of the Single-Vector Force Balance Calibration System (SVS). This study is focused on the uncertainty involved in setting the independent variables during the calibration experiment. By knowing the uncertainty in the calibration system, the fundamental limits of the calibration accuracy of a particular balance can be determined. A brief description of...

Mechanical resonators based on low-dimensional materials are promising for force and mass sensing experiments. The force sensitivity in these ultra-light resonators is often limited by the imprecision in the measurement of the vibrations, the fluctuations of the mechanical resonant frequency and the heating induced by the measurement. Here, we strongly couple multilayer graphene resonators to s...

Tunicamycin (Tm) sensitivity assays are a useful method for studies of endoplasmic reticulum stress and the unfolded protein response in eukaryotic cells. While Tm sensitivity and Tm recovery assays have been previously described, these existing methods are time-consuming, labor intensive, and subjected to mechanical wounding. This study shows an improved method of testing Tm sensitivity in Ara...

Artificial skin, which mimics the functions of natural skin, will be very important in the future for robots used by humans in daily life. However, combining skin's pressure sensitivity and mechanical self-healing properties in a man-made material remains a challenging task. Here, we show that graphene and polymers can be integrated into a thin film which mimics both the mechanical self-healing...

abstract: the main aim of the vibration energy harvesters is to locally power autonomous devices such as wireless sensors. generally, power levels are low and the environmental benefit of the technology is to replace batteries rather than saving energy per se. piezoelectric vibrational energy harvesters are usually inertial mass based devices, where a cantilever beam with a piezoelectric outer ...

In this paper, a new model for resonance frequency of clamped circular corrugated diaphragm has been presented. First, an analytical analyzes has been carried out to derive mathematic expressions for mechanical sensitivity of diaphragm with residual stress. Next by using Rayleigh's method we present mathematical model to calculate the resonance frequency of corrugated diaphragm and investigate ...

Advanced interferometric gravitational-wave detectors use optical cavities to resonantly enhance their shot-noise-limited sensitivity. Because of positive dispersion of these cavities-signals at different frequencies pick up different phases, there is a tradeoff between the detector bandwidth and peak sensitivity, which is a universal feature for quantum measurement devices having resonant cavi...

This study aims at improving the understanding of mechanisms responsible for cell sensitivity to extracellular environment. We explain how substrate mechanical properties can modulate the force regulation of cell sensitive elements primarily adhesion sites. We present a theoretical and experimental comparison between two radically different approaches of the force regulation of adhesion sites t...

Fiber Bragg grating (FBG) pressure sensors have the potential to replace conventional voltage due their compact size, resistance electromagnetic interference, excellent safety, distributed sensing, and numerous other intrinsic benefits. It is frequently employed in domains of civil engineering, aerospace, medicine. Our work examines two types sensitized FBG sensors, namely with innately improve...