INTRODUCTION The liver is the largest organ in the body weighing 1200-1500g. It is a key organ in regulating homeostasis within the body. It regulates several important functions including protein synthesis, storage and metabolism of fats and carbohydrates, detoxification of drugs and other toxins, metabolism of hormones and excretion of bilirubin. Liver diseases are associated with distortion ...

Although it has been well established that different species of marine algae have different sensitivities to metals, our understanding of the physiological and biochemical basis for these differences is limited. This study investigated copper adsorption and internalisation in three algal species with differing sensitivities to copper. The diatom Phaeodactylum tricornutum was particularly sensit...

We present the case of a 34-year-old male, admitted for progressive bilateral loss of vision after a recent episode of chickenpox. Ophthalmological exam revealed bilateral acute retinal necrosis. As the patient was following a drug detoxification program, he was tested for HIV, HVB, HVC, and results highly positive. Immediate intravenous therapy with high doses of acyclovir and methylprednisolo...

Protein lipoxidation is a non-enzymatic post-translational modification that consists of the covalent addition reactive lipid species to proteins. This occurs under basal conditions but increases in situations associated with oxidative stress. targets for include metabolic and signalling enzymes, cytoskeletal proteins, transcription factors, among others. There strong evidence involvement prote...

Mercury contamination in aquatic systems poses a serious environmental stress to phototrophic plankton. We used Euglena gracilis gain an understanding of the physiochemical changes resulting from mercury across transcriptome and metabolome. Using combination Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR-MS) RNA-sequencing, we identified metabolomic transcriptomic both with...