Background Cervical cancer is the second most common cancer in women and is regarded as one of the leading causes of cancer death in developing countries. In cervical cancer patients, both surgery and radiation therapy may bring about sexual dysfunction. Therefore, this study aimed to survey sexual dysfunction in women with cervical cancer and a history study of pelvic radiation therapy in Ghae...

Objective: To predict the risk factors of lymph node metastasis in cervical cancer by using large sample clinical data, and to construct verify nomogram for predicting metastasis. Methods: A total 5940 patients with from 2004 2015 National Cancer Institute Surveillance Epidemiology End Results database were retrospectively screened randomly assigned training group (n = 4172) validation 1768). M...

Mestastatic prostate cancer cells (MPCCs) frequently metastasize to bone, which is a “favorite soil” for colonization and proliferation of MPCCs. Prostate cancer bone mestastasis is tightly associated with tumor-induced bone lesions, most commonly caused from the etiological imbalance between osteoblastic bone formation and osteoclastic bone resorption, and from the anti-tumor immune response. ...

Gynecological cancers (GCs) include cervical, uterine, ovarian, vulvar and vaginal cancer. For women in China, 2 of the 10 most common are GCs (8th: cervical cancer, incidence rate: 3.96%; 10th: ovarian 2.91%). These can lead to enormous psychological economic burdens. Phosphatase tensin homolog (PTEN) gene protein kinase B (AKT) mammalian target rapamycin (mTOR) pathway widely involved develop...

Artesunate (ART) has anti-cancer activities for a variety of solid tumors. The aim of this study was to investigate the anti-metastatic effect of ART on cervical cancer cells. In vivo anti-metastatic effect of ART was investigated in mice with the lung metastasis model by the subcutaneous injection of ART. The interaction of HOTAIR and COX-2 was measured by RNA immunoprecipitation and RNA pull-...

Epithelial-mesenchymal transition (EMT) plays a critical role in promoting tumor invasion and metastasis. However, the key cofactors that modulate the signal transduction to induce EMT have note been fully explored to date. The present study reports that sine oculis homeobox homolog 1 (SIX1) is able to promote EMT of cervical cancer by coordinating with transforming growth factor (TGF)β-SMAD si...

introduction : cervical screening has decreased the incidence and mortality of cervical cancer worldwide. due to a low incidence rate of cervical cancer in iran and several middle eastern countries, an opportunistic screening is available for women in this region. we aimed to design and validate a questionnaire about knowledge, attitude, and practice (kap) for cervical cancer and cervical scree...

AIM This study aimed to analyze the expression, clinical significance of stanniocalcin 2 in cervical carcinoma patients who were treated with radiotherapy. METHODS Stanniocalcin 2 expression was determined by real-time PCR in 10 pairs of cervical cancer and adjacent normal cervical tissues. Tumor samples from 92 patients diagnosed from 2004 to 2007 were studied. All samples were obtained prio...

although acrometastases are rare but clinically they are considered important. their etiology is quite different from the metastases to other sites; bronchogenic carcinoma is by far the most frequent case. the prognosis is always similar to metastatic bronchial cancer with an average survival of three months. treatment may involve distal digital amputation or antalgic radiotherapy. the main dif...

despite the high rate of prostate cancer, the incidence of penile metastasis originating from prostate cancer is extremely rare, especially in the form of peyronie’s disease. moreover, brain metastasis, which is caused by prostate cancer, is not a common phenomenon and occurs mostly in older patients. herein, we report a case of a middle-aged man with penile and brain metastasis originating fro...