OBJECTIVE Proton magnetic resonance spectroscopy (1H-MRS) showed decreased neuronal marker N-acetylaspartate and increased glial marker myo-inositol in subjects with chronic methamphetamine use and in subjects infected with HIV. The authors sought to determine whether HIV and a history of chronic methamphetamine use might have additive or interactive effects on brain metabolite abnormalities. ...

results result shows that there is a significant difference between methamphetamine addicts and narcotics addicts and non-addicts in self-regulation and affective control (p = 0.001). conclusions this finding indicates that low self-regulation and affective control is a risky factor in psychoactive drugs abuse. materials and methods in this causative-comparative study, 80 addicts (40 methamphet...

One of the core objectives of supply-side drug law enforcement is to reduce drug use by raising the cost of buying drugs. The effectiveness of this strategy depends on how illicit drug users respond to the rise in costs. The aim of the current study was to estimate how methamphetamine users would respond to changes in the prices of methamphetamine and heroin, using hypothetical drug purchasing ...

A study was undertaken to develop demographic, toxicologic, and pathological profiles of methamphetamine-related deaths. Anatomic and toxicologic findings in 413 deaths where methamphetamine was detected were compared with findings in a control group of 114 drug-free trauma victims. The number of cases per year did not change significantly over the course of the study. Mean age was 36.8 years, ...

The novel transmembrane G protein-coupled receptor, trace amine-associated receptor 1 (TAAR1), represents a potential, direct target for drugs of abuse and monoaminergic compounds, including amphetamines. For the first time, our studies have illustrated that there is an induction of TAAR1 mRNA expression in resting T lymphocytes in response to methamphetamine. Methamphetamine treatment for 6 h ...

Aims: This qualitative study explores and characterises barriers to methamphetamine recovery that emerge from users discussing anonymously their challenges in an online discussion forum. Methods: Anonymous letters and stories (N1⁄4 202), which were submitted to an online support forum for methamphetamine users and their loved ones, were analysed in Dedoose software using grounded theory methodo...

PURPOSE OF REVIEW To describe and review the literature published on methamphetamine in 2003-2004, with a particular focus on patterns of use, its effects on the user and society, and progress being made towards effective treatment strategies. RECENT FINDINGS The methamphetamine epidemic continues to grow, dominating drug use trends in many parts of the world, and signifying an increasing nee...

BACKGROUND Against the background that crystal methamphetamine (colloquially known as "tik") is extensively used by the emerging working class Coloured youth in Cape Town, South Africa, this exploratory qualitative study was conducted to explore the experience of mothers whose children use methamphetamine. METHODS The researchers conducted one-to-one semi-structured in-depth interviews with s...