نتایج جستجو برای: methylglyoxal
تعداد نتایج: 1562 فیلتر نتایج به سال:
We show that two distinct distributions of F-actin are present in the hyphal apex of the oomycete Achlya bisexualis, that have been chemically fixed with a combination of methylglyoxal and formaldehyde and stained with Alexa phalloidin. In approximately one half of the hyphae examined, an F-actin depleted zone within the apical F-actin cap was observed. The remaining hyphae had a continuous api...
Advanced glycation end products (AGEs) are involved in the aging and the development of common chronic diseases. Hydroxytyrosol (HT) and its acetate derivative (HTA) exert a significant inhibitory activity on the formation of fluorescent AGEs in bovine serum albumin glycation model systems induced by methylglyoxal (IC50 value of 0.48 and 0.58 μmol/mL, respectively) and glucose (IC50 2.30 and 2....
1. Methylglyoxal synthase was purified over 1500-fold from glycerol-grown Escherichia coli K 12 strain CA 244. The purified enzyme was inactivated by heat or proteolysis, had a molecular weight of approx. 67000, a pH optimum of 7.5 and was specific for dihydroxyacetone phosphate with K(m) 0.47mm. 2. The possibility that a Schiff-base intermediate was involved in the reaction mechanism was inves...
Background and Aims. Adipose tissue dysfunction results from many factors, including glycation-induced microvascular damages. We tested the usefulness of inhibiting methylglyoxal-induced glycation to adipose tissue microvasculature in this work, using the antioxidant and dicarbonyl scavenger drug pyridoxamine. Methods. A group of Wistar rats was treated daily with methylglyoxal (MG, 75 mg/Kg/da...
The glycation of protein and nucleic acids that occurs as a consequence of hyperglycemia disrupts cell function and contributes to many pathologies, including those associated with diabetes and aging. Intracellular glycation occurs after the generation of the reactive 1,2-dicarbonyls methylglyoxal and glyoxal, and disruption of mitochondrial function is associated with hyperglycemia. However, t...
The fundamental investigations of Virtanen (1923, 1925), Virtanen and Karstrom (1931), and van Niel (1928) on the mechanism of glucose dissimilation by the propionic acid bacteria have led to the proposal that glucose after preliminary phosphorylation is converted into 2 molecules of the C) type. Virtanen upon theoretical considerations concludes that lactic acid is an intermediate product of t...
Methylglyoxal was a weak inhibitor of translation in the r e t i c u l o c y t e l y s a t e c e l l f r e e system and it did not display cap-dependent inhibition. A similar inhibition was obtained in a wheat-germ cei l f ree system that d i sp layed extensive cap-dependent inhibition with the cap ana logue 7 m e t h y J g u a n o s i n e phosphate . These results show that the chemical reacti...
We show that methylglyoxal forms lightabsorbing secondary organic material in aqueous ammonium sulfate and ammonium nitrate solutions mimicking tropospheric aerosol particles. The kinetics were characterized using UV-Vis spectrophotometry. The results suggest that the bimolecular reaction of methylglyoxal with an ammonium or hydronium ion is the rate-limiting step for the formation of light-abs...
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