Background: The use of nanotechnology has led to rapid growth in various areas. Thus, health and safety issues of nanoparticles (NPs) should be promptly addressed. Manganese oxide (MnO2) nanoparticles (NPs) are typically used for biomedical and industrial applications. However, characterizing the potential human health effects of MnO2 NPs is required before fully exploiting these materials. The...

Dopamine receptor-D2 (DRD2) is the most important drug target in prolactinoma. The aim of this current study was to investigate the role of using micro-positron emission tomography (micro-PET) with (18)F-fallypride and (18)F-fluorodeoxyglucose ((18)F-FDG) as molecular imaging tracer in the pituitary glands and prolactinomas of Fischer-344 (F344) rats and detect the difference of the levels of D...

The dorsal CA3 region of the hippocampus is unique in its connectivity, sensitivity to neurotoxic lesions, and its ability to encode and retrieve episodic memories. Computational models of the CA3 region predict that blocking mossy-fiber and/or perforant path activity to CA3 would cause impairments in learning and recall of spatial memory, respectively. Because the CA3 region contains micro-opi...

St. John's wort (SJW), a widely used herbal product, has been implicated in drug interactions resulting from the induced expression of the cytochrome P450 CYP3A4 isoform. In this study, we determined the effect of SJW on the metabolism of irinotecan, a pro-drug of SN-38 and a known substrate for CYP3A4. Five cancer patients were treated with irinotecan (350 mg/m(2), intravenously) in the presen...

The genus Helichrysum (Asteraceae) is comprised of approximately 500-600 species and used for the treatment of a variety of pathological conditions in folk medicine in many countries. In this study, antioxidant activities of aerial parts of H. pseudoplicatum were investigated employing various in vitro assay systems, i.e. 2,2-diphenyl-1-picrylhydrazyl (DPPH)  and nitric oxide radical scave...

Symbolic perturbation by innnitely small values removes degeneracies in geometric algorithms and enables programmers to handle only generic cases: there are a few such cases, whereas there are an overwhelming number of degenerate cases. Current perturbation schemes have limitations, presented below. To overcome them, this paper proposes to use an-arithmetic, i.e. to represent in an explicit way...

abstract this study was conducted to determine the impacts of different drip irrigation method and amount of water on yield and water use efficiency of tomato in varamin agricultural research center, iran. the study was done during two years. experimental design was randomized complete blocks design (rcbd) in split plot with three replications. three different drip irrigation method; surface dr...

security has two dimensions of subjective (security feeling) and objective. there are preconditions for security feeling in society that one of the preconditions, the existence of security in the society. these levels are linked together and the interaction between these two levels of objective and subjective that security in the society is achieved.therefore, in this article we have tried to e...

The presented study is motivated by the development of methods, algorithms, and software tools for μFE (micro finite element) simulation of human bones. The voxel representation of the bone microstructure is obtained from a high resolution computer tomography (CT) image. The considered numerical homogenization problem concerns isotropic linear elasticity models at micro and macro levels.