Hemoglobin K-Woolwich (Hb KW) is a rare hemoglobin variant with very few cases reported. It is most prevalent in West African countries, particularly Nigeria, Ghana, and the Ivory Coast. Some reports suggest Hb KW may be a clinically benign trait, whereas others indicate it may behave similarly to a β+ thalassemia. The combination of hemoglobin S and hemoglobin KW (Hb S/KW) is a rare double het...

BACKGROUND Anaemia is a common manifestation of paediatric HIV infection. Although there are many causes, anaemia of chronic diseases is the most frequent type. In poor countries iron deficiency is widespread. It is probable that many HIV-infected children in these countries are also iron deficient. This study describes the relationship between paediatric HIV infection and anaemia, and document...

Hemoglobin (Hb) A2 ( 2 2) constitutes less than 3% of the total hemoglobin (Hb) in adults and has almost no physiological importance.1 On the other hand, the determination of Hb A2 is an important tool to diagnose the beta-thalassemia trait (BTT).1,2 Although individuals with BTT do not need treatment, the accurate detection of the carrier state is important in genetic counseling to determine r...

Background < Iron deficiency anaemia (IDA) occurs in 2e5% of adult men and postmenopausal women in the developed world and is a common cause of referral to gastroenterologists. Gastrointestinal (GI) blood loss from colonic cancer or gastric cancer, and malabsorption in coeliac disease are the most important causes that need to be sought. Defining iron deficiency anaemia < The lower limit of the...

BACKGROUND Anemia is a frequent complication of infection with human immunodeficiency virus (HIV). The causes of HIV-related anemia are multifactorial. This study was conducted to evaluate the factors associated with anemia in HIV-infected patients. METHODS A total of 642 patients with HIV/AIDS attending the HIV Clinic at Imam Khomeini Hospital in Tehran, Iran enrolled in this study. A detail...

BACKGROUND Hexavalent chromium [Cr(VI)] is a human carcinogen after inhalation exposure. Humans also ingest Cr(VI) from contaminated drinking water and soil; however, limited data exist on the oral toxicity and carcinogenicity of Cr(VI). OBJECTIVE We characterized the chronic oral toxicity and carcinogenicity of Cr(VI) in rodents. METHODS The National Toxicology Program (NTP) conducted 2-ye...

Using the new Bayer H*3 hematology analyzer (Leverkusen, Germany), we have determined red blood cell and reticulocyte indices in 64 healthy subjects, in patients with microcytosis due to iron deficiency (58 patients) and heterozygous beta-thalassemia (40 patients), and in patients with macrocytosis (28 patients). We found in all cases that reticulocytes were larger than mature red cells by 24% ...

OBJECTIVE Sickle cell anemia and the interaction S/Beta thalassemia differ in hematological values due to microcytosis and hypochromia caused by the thalassemic mutation. The clinical benefit of long-term hydroxyurea treatment is undeniable in sickle cell disease with monitoring of the biological action of the drug being by the complete blood count. The objective of this work is to compare chan...

OBJECTIVE 1. To compare peripheral smear (PS) and Red cell distribution width (RDW) in diagnosis of Iron deficiency anemia (IDA) in various grades. 2. To study the changes in RDW and PS after therapy. METHODS Children in the age group of six months to five years with microcytic (MCV<80fl) anemia (Hemoglobin <11 g%) were evaluated. Those who had received blood transfusion and /or were already ...

Anaemia is defi ned by the haemoglobin concentration in peripheral blood being below the normal 14 gm/dL (SD ± 2) for women, 16 gm/dL (SD ± 2) for men and 12 gm/dL (SD ± 2) for children. The number of red blood cells is also usually reduced, below the normal 4.8 × 10/mm (SD ± 0.6) for women and 5.4 × 10/mm (SD ± 0.9) for men. The haematocrit is the proportion of red blood cells in the blood – n...