The severe combined immunodeficiency (SCID) mouse was investigated as a model system to study the growth and immunogenicity of human gliomas. Human glioma cell lines U-251MG, KNS-42, SF-188, A-172, and T-98G were injected subcutaneously into SCID mice. The cell lines U-251MG and KNS-42 grew as large, subcutaneous masses; SF-188, A-172, and T-98G did not grow. Glioma-immune system interactions w...

Let X be an irreducible complex analytic space with j : U →֒ X an immersion of a smooth Zariski open subset, and let V be a variation of Hodge structure of weight n over U . Assume X is compact Kähler. Then provided the local monodromy operators at infinity are quasiunipotent, IH(X,V) is known to carry a pure Hodge structure of weight k+n, while H(U,V) carries a mixed Hodge structure of weight ≥...

It is well known that in vitro subculture represents a selection pressure on cell lines, and over time this may result in a genetic drift in the cancer cells. In addition, long-term cultures harbor the risk of cross-contamination with other cell lines. The consequences may have major impact on experimental results obtained in various laboratories, where the cell lines no longer reflect the orig...

Transient expression of the tumor suppressor gene p53 via adenoviral-mediated gene transfer induces apoptosis in glioma cells expressing mutant p53, while causing cell cycle arrest in cells with wild-type p53. To determine whether a change in p53 status of a wild-type p53-expressing cell line such as U-87 MG would alter its apoptotic resistant phenotype in response to Ad-p53 infection, we gener...

Due to the variety of products, simultaneous production of different models has an important role in production systems. Moreover, considering the realistic constraints in designing production lines attracted a lot of attentions in recent researches. Since the assembly line balancing problem is NP-hard, efficient methods are needed to solve this kind of problems. In this study, a new hybrid met...

Two of the most important broad classifications of phenotypes for successful dairy production are milk yield and fertility. The nature of the relationship between milk production and reproductive performance of dairy cows is uncertain due to conflicting results reported in many studies. A common deficiency in many such studies is an underappreciation of the dual dimension of the production-repr...

This study considers scheduling in Hybrid flow shop environment with unrelated parallel machines for minimizing mean of job's tardiness and mean of job's completion times. This problem does not study in the literature, so far. Flexible flow shop environment is applicable in various industries such as wire and spring manufacturing, electronic industries and production lines. After modeling the p...

Mixed-model assembly line (MMAL) is a type of production line where a variety of product models similar to product characteristics are assembled. Line balancing and model sequencing problems are important for an efficient use of such lines. This paper presents integer programming formulation and a solution for a loading and assembly plan selection problem in a mixed-model assembly system. The p...

Calibrated weighting methods for estimation of survey population characteristics are widely used. At the same time, model-based prediction methods for estimation of small area or domain characteristics are becoming increasingly popular. This paper explores weighting methods based on the mixed models that underpin small area estimates to see whether they can deliver equivalent small area estimat...