An algorithm for dynamic multileaf-collimator (dMLC) tracking of a target performing a known a priori, rigid-body motion during volumetric modulated arc therapy (VMAT), has been experimentally validated and applied to investigate the potential of the Agility (Elekta AB, Stockholm, Sweden) multileaf-collimator (MLC) for use in motion-compensated VMAT delivery. For five VMAT patients, dosimetric ...

Phosphorylation of the 20-kDa regulatory myosin light chain (MLC) of smooth muscle is known to cause monomeric myosins in solution to self-assemble into thick filaments. The role of MLC phosphorylation in thick filament formation in intact muscle, however, is not clear. It is not known whether the phosphorylation is necessary to initiate thick filament assembly in vivo. Here we show, by using a...

Phosphorylation of myosin light chain (MLC) and contraction of differentiated smooth muscle cells in vascular walls are regulated by Ca2+ -dependent activation of MLC kinase, and by Rho-kinase- or protein-kinases-C-dependent inhibition of MLC phosphatase (MLCP). We examined regulatory pathways for MLC kinase and MLCP in cultured vascular smooth muscle cells (VSMCs), and for isometric force gene...

The emergence of resistant microorganisms towards standard antibiotics has stimulated an on-going exploration for new sources antimicrobials. microbial susceptibility extracts produced from leaf, bark, or rhizome parts nine different New Zealand bushes was investigated using liquid broth dilution and agar plating techniques. Minimum inhibitory (MIC) lethal concentrations (MLC) were expressed in...

Background: Before treatment planning and dose delivery, quality assurance of multi-leaf collimator (MLC) has an important role in intensity-modulated radiation therapy (IMRT) due to the creation of multiple segments from optimization process.Objective: The purpose of this study is to assess the quality control of MLC leaves using EBT3 Gafchromic films.Material and Methods: Leaf Position accur...

Machine learning involves the task of training systems to be able make decisions without being explicitly programmed. Important among machine tasks is classification involving process machines predictions from predefined labels. Classification broadly categorized into three distinct groups: single-label (SL), multi-class, and multi-label (ML) classification. This research work presents an appli...

The multi-level cell (MLC) NAND flash memory technology enables multiple bits of information to be stored on a single cell, thus making it possible to increase the density of the memory without increasing the die size. For most MLC flash memories, each cell can be programmed as a single-level cell or a multi-level cell during runtime. Therefore, it has a potential to achieve both the high perfo...

Aggregatibacter actinomycetemcomitans, a periodontal pathogen, synthesizes leukotoxin (LtxA), a protein that helps the bacterium evade the host immune response. Transcription of the ltxA operon is induced during anaerobic growth. The cyclic AMP (cAMP) receptor protein (CRP) indirectly increases ltxA expression, but the intermediary regulator is unknown. Integration host factor (IHF) binds to an...

Oxidized low-density lipoproteins (oxLDL) generated in the hyperlipidemic state may contribute to unregulated platelet activation during thrombosis. Although the ability of oxLDL to activate platelets is established, the underlying signaling mechanisms remain obscure. We show that oxLDL stimulate platelet activation through phosphorylation of the regulatory light chains of the contractile prote...

By jointly analyzing multiple variants within a gene, instead of one at a time, gene-based multiple regression can improve power, robustness, and interpretation in genetic association analysis. We investigate multiple linear combination (MLC) test statistics for analysis of common variants under realistic trait models with linkage disequilibrium (LD) based on HapMap Asian haplotypes. MLC is a d...