Cytochrome c oxidase (CIV) deficiency is one of the most common respiratory chain defects in patients presenting with mitochondrial encephalocardiomyopathies. CIV biogenesis is complicated by the dual genetic origin of its structural subunits, and assembly of a functional holoenzyme complex requires a large number of nucleus-encoded assembly factors. In general, the functions of these assembly ...

Assembly lines are the most commonly used method for a mass production environment. Their main purpose is to increase efficiency by maximizing the ratio between throughput and required costs. However, in the last few decades, market demands have changed enormously. The emphasis is now on shorter lead times, larger product variety, higher quality and more customized options. At the same time, so...

In this paper we develop a multi-objective model to optimally control the lead time of a multistage assembly system. The multistage assembly system is modeled as an open queueing network, whose service stations represent manufacturing or assembly operations. The arrival processes of the individual parts of the product, which should be assembled to each other in assembly stations, are assumed to...

Five out of six human melanoma cell lines tested were able to degrade in vitro a smooth muscle cell extracellular matrix in a plasmin-dependent way. In three of these five cell lines, this process was mediated by tissue-type plasminogen activator (t-PA) and in the other two cell lines by urokinase-type plasminogen activator (u-PA). All melanoma cell lines produced t-PA mRNA and protein, whereas...

This research addresses the mixed-model assembly line (MMAL) by considering various constraints. In MMALs, several types of products which their similarity is so high are made on an assembly line. As a consequence, it is possible to assemble and make several types of products simultaneously without spending any additional time. The proposed multi-objective model considers the balancing and sequ...