In this work, we introduce a new method for the sensitivity analysis of model output in the presence of …nite changes in one or more of the exogenous variables. We de…ne sensitivity measures that do not rest on di¤erentiability. We relate the sensitivity measures to classical di¤erential and comparative statics indicators. We prove a result that allows us to obtain the sensitivity measures at t...

paper studies the modified sensitivity analysis applied into an elastic-plastic finite element analysis of a 3D blank design in sheet metal forming. Originally the sensitivity method has successfully been applied to several arbitrary shapes. In the present paper the sensitivity coefficients are not considered constant during the analysis. The presented approach computes the new coefficients fro...

The minimal model is widely used to evaluate insulin action on glucose disappearance from frequently sampled intravenous glucose tolerance tests (FSIGT). The common protocols are a regular (rFSIGT, single injection of 0.3 g/kg of glucose) and an insulin-modified test (mFSIGT, with an additional insulin administration at 20 min). This study compared the insulin sensitivity index (SI) and glucose...

BACKGROUND Differences in spontaneous and drug-induced baroreflex sensitivity (BRS) have been attributed to its different operating ranges. The current study attempted to compare BRS estimates during cardiovascular steady-state and pharmacologically stimulation using an innovative algorithm for dynamic determination of baroreflex gain. METHODOLOGY/PRINCIPAL FINDINGS Forty-five volunteers unde...

Biogenic sources contribute a large portion of emissions of volatile organic compounds (VOCs), a precursor to tropospheric ozone (O3). These emissions are difficult to control and are affected by land-use and climate. A sensitivity analysis was performed using an emissions scenario with a 100% increase in biogenic emissions and another scenario with an additional 100% increase in motor vehicle ...

Naphthol isomers were simultaneously and spectrophotometrically determined in wastewater, using a model based on net analyte signal (NAS). The calibration method used is a variation of the original hybrid linear analysis method as proposed by Goicoechea and Olivieri (HLA/GO). Owing to spectral interferences, the simultaneous determination of mixtures of naphthol isomers, using a spectrophotomet...

conclusions the use of tdf in patients with hbeag-negative chb seemed to be a highly cost-effective strategy. compared with the other available medication options, tdf was the most cost-saving strategy. thus, tdf may be the best option as a first-line medication. patients can also be switched from other medications to tdf. results the results revealed that the tdf treatment strategy was more ef...