OBJECTIVE Offspring of bipolar parents have a genetically increased risk of developing mood disorders. In a longitudinal study, the authors followed a bipolar offspring cohort from adolescence into adulthood to determine the onset, prevalence, and early course of mood disorders and other psychopathology. METHOD The Dutch bipolar offspring cohort is a fixed cohort initiated in 1997 (N=140; age...

introduction: breast cancer with 22.6% is the most common cancer in iranian women and mastectomy is the treatment of choice in 81% of cases posted for surgery. mastectomy can evoke feelings of mutilation, altered body image and decreased sexual attractiveness and function leading to mood disorders. in the last decades, final purpose of treatment strategies in breast cancer is creation of a life...

INTRODUCTION Treatment nonresponse in adolescent mood disorders is a major public health problem, as mood disorders in youth are associated with significant mortality by suicide, protracted course of illness, and recurrence into adulthood. Three studies with small sample sizes exist for lamotrigine in youth mood disorders. However, the risk of serious rash has limited its use in youth mood diso...

Objective. The aim of the present study is to evaluate the link between the age of onset of mood disorders and the complexity of the personality traits. Methods. 209 patients with major depressive or manic/hypomanic episodes were assessed using the Structured Clinical Interview for DSM Axis I diagnoses and the Millon Clinical Multiaxial Inventory-III (MCMI-III). Results. 17.2% of the patients h...

Introduction Suicide is a complex and multicausal phenomenon. It has a strong association with mental disorders, particularly major depressive disorder. Suicidal behaviors (both fatal and non-fatal) in patients with mood disorders are determined by their severity. Suicidal acts likely occur during depressive episodes, less often during mixed states, and very rarely in hypomania. However, the pr...

Recent post-mortem and imaging studies provide evidence for a glial reduction in different brain areas in mood disorders. This study was aimed to test whether glial cell line-derived neurotrophic factor (GDNF), a member of transforming growth factor (TGF)-beta superfamily, in blood levels was associated with mood disorders. We measured GDNF and TGF-beta levels in whole blood in remitted patient...

ôbjective: the mood disorder questionnaire (mdq) has been developed as a self-reporting, brief, and easy-to-use screening instrument to improve identification of bipolar mood disorders. the goals of the present study were to examine the prevalence of this disorder and interrelationship of its symptoms by factor analysis of mdq in a group of pregnant women in ïran. methods: ône thousand and eigh...

BACKGROUND Deep brain stimulation of the subthalamic nucleus (STN DBS) reduces Parkinson disease (PD) motor symptoms but has unexplained, variable effects on mood. OBJECTIVE The study tested the hypothesis that pre-existing mood and/or anxiety disorders or increased symptom severity negatively affects mood response to STN DBS. METHODS Thirty-eight PD participants with bilateral STN DBS and ...