Recent clinical trials using antibodies with low toxicity and high efficiency have raised expectations for the development of next-generation protein therapeutics. However, the process of obtaining therapeutic antibodies remains time consuming and empirical. This review summarizes recent progresses in the field of computer-aided antibody development mainly focusing on antibody modeling, which i...

Abstract Background and Aim: High chipping rates of the veneering porcelain of zirconia ceramic restorations have been reported in clinical studies. Thus, the shear bond strength (SBS) between the zirconia core and veneering porcelain requires investigation. Materials and Methods: In this in-vitro study, at first, using a computer-aided design/computer-aided manufacturing (CAD/CAM) machine, 1...

According to the working principle of spherical hob, computing formulae of normal and axial profile of the spherical hob are deduced, and calculation methods of other main parameters are introduced in the paper. Then the computer aided design and calculation of spherical hob is realized by Visual Basic programming language, which increases the calculation speed and accuracy. And the new manufac...

Computer-aided drafting and design (CADD) is a computer-based program that improves the efficiency of product design and components both inside and outside of engineering. In recent years the use of CADD in dentistry, more commonly known as computer-aided dentistry, has become commonplace, allowing doctors and patients to individually design treatment with the result visible through computer-ge...