Exposure of aquatic organisms to antidepressants is currently well documented, while little information available on how wild cope with exposure these pharmaceutical products. Studies antidepressant metabolism in exposed could generate their detoxification pathways and pharmacokinetics. The goal this study was enhance knowledge the venlafaxine (VEN)—an frequently found ecosystems—in Mytilus gal...

BACKGROUND Since 2009, the Hemorrhagic Fever with Renal Syndrome (HFRS) Targeted Expanded Program on Immunization (EPI) has been carried out in the 16-60 age population in Yichun City of Jiangxi Province. However, the annual reported incidences of HFRS in Yichun City Increased significantly from 2009 to 2013. MATERIAL/METHODS The information on HFRS reported cases were obtained from the China...

Microbeams are ideally suited to the study of so-called ‘non-targeted’ phenomena that are now known to occur when living cells and tissues are irradiated. Non-targeted effects are those where cells are seen to respond to ionising radiation through pathways other than direct damage to the DNA. One such phenomenon is the ‘bystander effect’; the observation that unirradiated cells can be damaged t...

Active targeting could increase the efficacy of anticancer drugs. Methotrexate-human serum albumin (MTX-HSA) conjugates, functionalized by luteinizing hormone-releasing hormone (LHRH) as targeting moieties, with the aim of specifically targeting the cancer cells, were prepared. Owing to the high expression of LHRH receptors in many cancer cells as compared to normal cells, LHRH was used as the ...

BACKGROUND The objective of this study was to evaluate the expression levels of glycolytic markers, especially hexokinase-2 (HK2), using a three-dimensional multicellular spheroid model of human ovarian adenocarcinoma (SKOV-3) cells and to develop an epidermal growth factor receptor-targeted liposomal formulation for improving inhibition of HK2 and the cytotoxicity of 3-bromopyruvate (3-BPA). ...