The use of diethyl pyrocarbonate as a nuclease inhibitor in the preparation of RNA of high molecular weight has prompted a study of the possible reactions of this compound with nucleic acid components under the conditions generally employed for providing inhibition. The first substrate investigated was adenine, which has been found to undergo ring opening with the formation of 5(4)-N-carbethoxy...

Short oligonucleotides below 8-10 nt in length adopt relatively simple structures. Accordingly, they represent interesting and so far unexplored lead compounds as molecular tools and, potentially, for drug development as a rational improvement of efficacy seem to be less complex than for other classes of longer oligomeric nucleic acid. As a 'proof of concept', we describe the highly specific bi...

Extracellular Vesicles and Circulating Nucleic Acids is an open access journal, focusing on extracellular vesicles circulating nucleic acids including DNA, RNA, miRNA their therapeutic use.

Extracellular Vesicles and Circulating Nucleic Acids is an open access journal, focusing on extracellular vesicles circulating nucleic acids including DNA, RNA, miRNA their therapeutic use.

Extracellular Vesicles and Circulating Nucleic Acids is an open access journal, focusing on extracellular vesicles circulating nucleic acids including DNA, RNA, miRNA their therapeutic use.

While the early workers in this field, such as Miescher and Hopne-Seyler, appear t,o have conjectured the macromolecular and complex chaaacter of the nucleic acids that they were the first to isolate, this view soon was abandoned in favor of the chemically more attractive tetranucleotide hypothesis, and those students of nucleic acid chemistry (e.g. (1, 2)) who still felt that much remained to ...

Abstract “ They call it life, we pollution ” is an infamous quote which ignores many facts about why carbon dioxide (CO 2 ) poses a significant problem for the ocean. But before get to this, let’s start at beginning. All organisms on Earth require particular set of elements growth. In case plants, these are needed synthesise organic matter in process called primary production via photosynthesis...

Extracellular Vesicles and Circulating Nucleic Acids is an open access journal, focusing on extracellular vesicles circulating nucleic acids including DNA, RNA, miRNA their therapeutic use.