نتایج جستجو برای: nucleotide polymorphism
تعداد نتایج: 201089 فیلتر نتایج به سال:
background: hypospadias is one of the most common congenital abnormalities in the male which is characterized by altered development of urethra, foreskin and ventral surface of the penis. androgen receptor gene plays a critical role in the development of the male genital system by mediating the androgens effects. objective: in present study, we looked for new variations in androgen receptor pro...
Avian reoviruses (ARVs) are considered as an important cause of several diseases in poultry, particularlyarthritis and tenosynovitis. Tenosynovitis and arthritis, which are among the causes of chronic lameness inbreeder flocks, can result in reduced egg production and culling of breeder hens. In this study, the molecularcharacteristics of ARVs in some broiler breeder flocks were investigated in...
Introduction: Endometriosis is a prevalent gynecological disorder among women which is diagnosed by the growth of endometrial tissue outside of uterus and is mainly accompanied by severe pelvic pain and infertility. P53 also known as cellular tumor antigen P53 inside codons 11, 72 and 248 are contained with single nucleotide changes in which tends to be nearly rampant.This will probably b...
Background and purpose: Estrogen hormone is a physiological regulator of breast tissue proliferation and changes in its signaling pathways, including the alpha-estrogen receptor, occurs during breast cancer and its progression. Single-nucleotide polymorphisms (SNPs) in genes can lead to differences in cancer susceptibility and response to treatment in different populations. In the present study...
OBJECTIVE To explore the frequency and significance of ApoE gene polymorphisms in patients with sporadic Alzheimer's disease (AD). METHODS Single nucleotide polymorphisms of the ApoE gene were analyzed in 32 cases of AD and 26 controls, using PCR and gene sequencing. RESULTS The single nucleotide polymorphism of ApoE gene 462C/G was significantly associated with AD (P < 0.05). CONCLUSIONS...
Background and Aim: A single nucleotide polymorphism at codon 72 of the p53 gene alters the p53 protein structure and affects its activity. This polymorphism depends on geographic regions and race. Also its association with some cancers has been reported. The aim of this study was to investigate this polymorphism in well differentiated oral SCC and normal population in the city of Isfahan. Mat...
Background: Single nucleotide polymorphisms (SNPs) have been introduced as a new genomic source for cancer. Therefore, it was decided to conduct a study to evaluate the rs3746444 polymorphism of miR-499 in patients with colon cancer in comparison with healthy subjects. Methods: This case-control study was conducted to investigate rs3746444 polymorphism of miR-...
Objective Matrix Metalloproteinase (MMPs) play important roles in the structural and functional properties of reproductive organs. The aim of this study is to determine the prevalence of C-1562T Matrix Metalloproteinase-9 (rs3918242) gene polymorphism in fertile and infertile men. In addition, we aimed to determine the association between C-1562T MMP-9 and G-1575A MMP-2 gene polymorphisms. Mate...
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