INTRODUCTION The principal mechanisms of ventilator induced lung injury (VILI) have been investigated in numerous animal studies. However, prospective data on the effect of old age on VILI are limited. Under the hypothesis that susceptibility to VILI is increased in old age, we investigated the pulmonary and extrapulmonary effects of mechanical ventilation with high tidal volume (VT) in old com...

conclusions our data has provided baseline information about epidemiologic aspects of oral mucosal lesions which can be valuable in organized national program targeting on oral health and hygiene in the society. results the prevalence of mucosal lesions in our study was 19.4%. our data demonstrated higher prevalence of oral mucosal lesions in males and young adults (30-40 years). the most commo...

in a preliminary experiment. the protective effects of ' peritoneal macrophages was shown by transferring macroph. ages fr-om adult mice to newborn and to 7 and 14 days old mice. it suckling mice from intraperitoneal infection with mcmv by reducing the mortality rate from 100% to 27%.was demontrated that such transplentatton protect

Abstract Intestinal malrotation presents as an emergency in the neonate and within first year of life. Incomplete intestinal rotation may remain asymptomatic undiagnosed. Adult patients are usually diagnosed incidentally while being investigated for nonspecific abdominal symptoms. We report a case 43-year-old female who presented with 10-day history paraumbilical pain. Computed tomography demon...

Muscle atrophy is one of the consequences of aging and sports activities may prevent it. The aim of this study was to evaluate the effect of high intensity interval training on gene expression of Tweak and Fn14 in EDL muscle of aged C57bl/6 mice. For this purpose, 28 male C57bl/6 mice aged (n=14) and adult (n=14) were assigned in two groups of training (n=7) and control (n=7). After one-week fa...

Damaged articular cartilage rarely heals or regenerates in middle-aged and elderly adults, suggesting that the chondrogenic potential of mesenchymal stem cells declines with age. To test this hypothesis, we measured the responses of rat bone marrow-derived mesenchymal stem cells (BMSCs) to chondrogenic induction in vitro. BMSCs from immature rats (1 week old), young adult rats (12 weeks old), a...

The decreased natriuretic action of dopamine in the young has been attributed to decreased generation of cAMP by the activated renal D(1)-like receptor. However, sodium/hydrogen exchanger (NHE) 3 activity in renal brush-border membrane vesicles (BBMV) can be modulated independent of cytoplasmic second messengers. We therefore studied D(1)-like receptor regulation of NHE activity in BBMVs in 2-,...

Many researches have been conducted in experimental models in order to study the development of atherosclerosis from hyperlipidemia-inducing diets. Since rabbits are very sensitive to cholesterol-rich diets and accumulate large amounts of cholesterol in their plasma, their use as experimental models to evaluate the development of atherosclerosis is highly relevant and brings information on fact...

Macrophages can change their phenotype in response to environmental cues. Polarized macrophages are broadly classified into two groups: classical activated M1 and alternative activated M2. Characterization of human macrophages has been widely studied, but polarized macrophages in rabbits have not been characterized. We characterized rabbit macrophages that were polarized using human recombinant...