culture, likely by decreasing P phosphorylation and thus viral protein transcription and expression. Activation of AKT during RSV infection likely involves the NS2 protein and does not depend on the PH domain of AKT. AKT inhibitors have been found to be safe and efficacious in clinical trials for a number of different cancers; thus, AKT inhibition may be a potential therapeutic treatment for se...

Life and death decisions are made by integrating a variety of apoptotic and survival signals in mammalian cells. Therefore, there is likely to be a common mechanism that integrates multiple signals adjudicating between the alternatives. In this study, we propose that 14-3-3 represents such an integration point. Several proapoptotic proteins commonly become associated with 14-3-3 upon phosphoryl...

The human T-cell leukemia virus type I (HTLV-I) and HTLVII Tax proteins are potent transactivators of viral and cellular gene expression. Using deletion mutants, the downstream parathyroid hormone-related protein (PTHrP) promoter is shown to be responsive to both HTLV-I and HTLV-II Tax as well as the AP1 /c-jun proto-oncogene. Transactivation of PTHrP by Tax was seen in T cells but not in B-cel...

PURPOSE MicroRNAs (miRNAs) are endogenously expressed, small noncoding RNAs that inhibit gene expression by binding to target mRNAs. Recent studies have revealed that miRNAs function as tumor suppressors or oncogenes. In the present study, we investigated the role of miRNA-34b/c in uveal melanoma. METHODS Real-time reverse transcriptase polymerase chain reaction (RT-PCR) was performed to dete...