background: melanoma causes the greatest morbidity and mortality of all skin cancers. mucosal melanoma is a rare but highly aggressive neoplasm. according to previous studies the prevalence of kit mutations in acrallentiginous and mucosal melanomas is relatively low (less than 15–20%), but it can have profound therapeutic implications for localized high risk or metastatic diseases. our goal was...

materials and methods twelve natural compounds jaceosidin, withaferin a, curcumin, epigallocatechin-3-gallate (egcg), artemisinin, gingerol, ursolic acid, ferulic acid, berberin, silymarin, resveratrol, and indol-3-carbinol were docked against e6 and e7 oncoproteins of high-risk hpv types 16 and 18 using a protein-ligand docking software called autodock4.2. results out of these 12 natural compo...

Abstract This invited Team Profile was created by Kevin Li and Liliya Yatsunyk, Swarthmore College PA (USA) John Schneekloth, Jr, (Jay) National Cancer Institute, Frederick MD . They recently published an article on the first crystal structure of intercalated motif (i‐motif or iM) from HRAS oncogene involved in many cancers. The iHRAS solved to 1.8 Å resolution. It contains a tail‐to‐tail dimer...

transforming growth factor atpha (tgf-a), parathyroid hormone-tike proteins (pthlp) and oncogene p53 proteins have all been demonstrated in a variety of human tumors anil have been implicated as causes of tumor cell aggressiveness. the present study determined the existence of these peptides and their immunohistochemicat profiles in ameloblastomas. odontogenic keratocysts and dentigerous cysts ...

objective: breast cancer is the most common cause of cancer-related deaths in women both worldwide and in malaysia. azadirachta indica (a. juss), commonly known as neem, is one of the most versatile medicinal plants that has gained worldwide prominence due to its medicinal properties. however, the anticancer effect of ethanolic neem leaf extract against breast cancer has not been documented. th...

background & objective: the current approaches to reduce the risk of colorectal carcinoma are through the detection and removal of the precursor lesion” adenomatous polyps”. the study was conducted to evaluate the immunohistochemical expression of p53 and bcl2 in colorectal adenomas and carcinomas. patients and methods: a total of 86 cases, 33 colorectal adenomas, 33 colorectal adenocarcin...

In this communication we report, for the first time, the ring-opening polymerisation in the melt of rac-lactide with heterogeneous catalysts. Homogeneous model systems based on silsesquioxanes have been prepared for comparison.