background: direct thrombin inhibitors and factor xa inhibitors are gaining popularity as alternatives to warfarin for patients requiring anticoagulation. toxicity due to these medications is difficult to manage because overdose experience is very limited and there is no clear guidance on when or whether to use antidote in this setting. case presentation: a 50-year-old man with normal renal fun...

Heroin overdose deaths are preventable. Overdose prevention in Australia has largely rested on opioid substitution treatment supplemented with outreach services and education for injecting drug users (IDUs) about overdose risks and responses. We believe now is the time to make naloxone hydrochloride (Narcan ®) available to Australian IDUs to help prevent overdose deaths. At the end of 2000 hero...

BACKGROUND Overdose from illicit drugs is a leading cause of premature mortality in North America. Internationally, more than 65 supervised injecting facilities (SIFs), where drug users can inject pre-obtained illicit drugs, have been opened as part of various strategies to reduce the harms associated with drug use. We sought to determine whether the opening of an SIF in Vancouver, BC, Canada, ...

OBJECTIVE To assess whether injecting drug users have a higher than usual risk of death from overdose in the 2 weeks after release from prison. DESIGN Soundex coding of surnames and information on date of birth were used to link entry and release dates from the local prison between 1983 and 1994 with clinical data from Edinburgh City Hospital's cohort of male injecting drug users who are infe...

abstract background: suicide is a major problem world-wide. the aim of this study was to determine the incidence of suicide in east azerbaijan province, iran. methods: a cross-sectional study conducted from 2010 to 2011. we analysed some characteristics of the cases of suicide based on the health system database. variables such as demographics, outcomes (fatal/nonfatal), and methods used were r...

conclusions lithium intoxication should be considered in the differential diagnosis, especially in elderly patients on lithium therapy who are admitted to the emergency department with chest pain. case presentation a 62-year-old woman was admitted to the emergency department due to weakness and acute chest pain. her ecg revealed st elevation in leads di, avl and v5-6, with a ventricular rate of...

background:every day, people with addiction cause heavy economic and cultural damage to society. in some circumstances, opioids are used as a tool for suicide, which is often seen in youth. the aim of this study was to investigate the clinical signs of toxicity associated with opium in patients referred to ardabil city hospital. methods:this is a cross-sectional study that has been done on opiu...