Oxidative stress is increasingly implicated as a co-factor of tissue injury in inflammatory/demyelinating disorders of the central nervous system (CNS), such as multiple sclerosis (MS). While rodent experimental autoimmune encephalomyelitis (EAE) models diverge from human demyelinating disorders with respect to limited oxidative injury, we observed that in a non-human primate (NHP) model for MS...

It has long been recognized that simultaneous exposure to heat stress and oxidative stress shows a synergistic interaction that reduces organismal fitness, but relatively little is known about the mechanisms underlying this interaction. We investigated the role of molecular stress responses in driving this synergistic interaction using the nematode Caenorhabditis elegans To induce oxidative str...

Oxidative stress (OS) is widely believed to be responsible for the generation of trade-offs in evolutionary ecology by means of constraining investment into a number of components of fitness. Yet, progress in understanding the true role of OS in ecology and evolution has remained elusive. Interpretation of current findings is particularly hampered by the scarcity of experiments demonstrating wh...

objective: this study was conducted with the aim to investigate and compare iranian produced and foreign oxytocin for use in induction of labor. materials and methods: this random clinical trial was conducted on a population of 198 pregnant women with live fetus and cephalic presentation and conditions conducive to induction of labor, monitored by obstetricians and gynecologists. they were rand...

Effects of different concentrations [0, 1, 5, 10, 20 and 40 mgL-1] of Fe3O4 and CuO nano-particles (nFe3O4 and nCuO) were investigated on sulforaphane (SFN) production level in 7-day-old seedlings of Lepidium draba at different time intervals (8 and 16 hrs). According to the results, the influence of the particles on SFN contentdepends on nano-particle (NP) concentrations, time of treatment as ...

neopterin, apyrazinopyrimidine compound, is produced by macrophages after induction by interferon gamma (ifn-y) and serves as a marker of cellular immune system activation followed by oxidative stress. the aim of this study was to determine urinary neopterin to creatinine ratio (uncr) as a surrogate marker of cell-mediated immune activation in multiple sclerosis (ms). three weekly early morning...

Abstract Neurodegenerative disorders are associated with causes such as induction of oxidative stress, alterations in Ca 2+ homeostasis, abnormal protein aggregation, inflammatory processes, excitotoxicity, and apoptosis. In addition to the above, food transition recent years has led changes dietary patterns, increasing consumption ultra-processed processed foods that can lead lipotoxicity indu...

Traditional medicines are clinically used to treat post-stroke disorders in China. In search of alternative medicines for post-stroke rehabilitation, we recently identified the heme oxygenase-1 (HO-1) pathway as a key mechanism underlying the biological activities of the ischemic stroke formulation ISF-1. This study was designed to further investigate ISF-1 for HO-1 induction in cultured human ...

In this study, we examined cardiac inflammation, fibrosis and left ventricular (LV) function during the development of streptozotocin (STZ)-induced diabetic cardiomyopathy using an animal model of diabetes mellitus (DM). Diabetes was induced in 22 Sprague‑Dawley rats by an intraperitoneal single injection of STZ (70 mg/kg). Non-diabetic animals served as the controls (n=6). LV function was docu...