A prolonged Bazett corrected QT (QTcB) either congenital or acquired is one of the primary risk factors in development ventricular arrhythmias and sudden cardiac death children. QTcB determination notoriously problematic for non-pediatric cardiologists currently available automatic electrocardiogram (ECG) interpreters. We set out to develop validate a deep neural network (DNN) measure diagnose ...

Abstract Background 25-hydroxyvitamin D is the recommended target to evaluate vitamin status. The accurate measurement of by liquid chromatography/mass spectrometry (LC/MS/MS) impacted presence biologically inactive epimer D2 and D3, 3-EPI-25-hydroxyvitamin D3. epimers are isomers share same mass fragment transitions as For an should be chromatographically separated from D. Herein we assess sig...

Fluconazole is a first-line antifungal agent for the treatment and prophylaxis of invasive candidiasis in pediatric patients. Pediatric patients are at risk of suboptimal drug exposure, due to developmental changes in gastrointestinal and renal function, metabolic capacity, and volume of distribution. Therapeutic drug monitoring (TDM) can therefore be useful to prevent underexposure of fluconaz...

BACKGROUND Over the past decade laboratories that test for metabolic disorders have introduced tandem mass spectrometry (MS/MS), which is more sensitive, specific, reliable, and comprehensive than traditional assays, into their newborn-screening programs. MS/MS is rapidly replacing these one-analysis, one-metabolite, one-disease classic screening techniques with a one-analysis, many-metabolites...

In this paper, we describe the processing and verification work undertaken to migrate WordStar for MSDOS to HTML4 formatted files. General Terms Preservation strategies and workflows, specialist content types, digital preservation marketplace, theory of digital preservation, case studies and best practice.

Piracetam was subjected to the hydrolytic, oxidative, thermal and photolytic stress, according to ICH guideline Q1A (R2). The drug depicted degradation only in basic conditions, while it was stable to other stress conditions (acidic, neutral hydrolysis, thermal and photolytic conditions). A total of one degradation product was formed, which were separated on a BEH column employing an isocratic ...

Atypical or idiosyncratic language is a characteristic of autism spectrum disorder (ASD). In this paper, we discuss previous work identifying language errors associated with atypical language in ASD and describe a procedure for reproducing those results. We describe our data set, which consists of transcribed data from a widely used clinical diagnostic instrument (the ADOS) for children with au...

The aim of this study was to estimate the prevalence of metabolic syndrome (MS) and its components in obese Mexican adolescents and to compare the clinical, anthropometric, and biochemical characteristics between patients with and without MS by sex. We conducted a cross-sectional study with a sample of 110 obese adolescents (boys and girls) from 8 to 16 years old (BMI ≥95th percentile), who wer...

from Viral Shedding? Robert Schlaberg, MD, MPH; Krow Ampofo, MD; Keith Tardif, PhD; Chris Stockmann, MSc; Keith Simmon, MS; Weston Hymas, MS, MB(ASCP); Steven Flygare, MS; Brett Kennedy, PhD; Anne J. Blaschke, MD, PhD; Karen Eilbeck, PhD; Mark Yandell, PhD; Anna M. Bramley, MPH; Seema Jain, MD, MPH; Andrew Pavia, MD, FIDSA, FSHEA; Department of Pathology, University of Utah, Salt Lake City, UT;...