Pathological arterial blood flow generates fluid shear stresses that directly cause platelet aggregation. The mechanism of shear-induced platelet aggregation is incompletely understood, but involves von Willebrand factor (vWF) binding to platelet glycoprotein (GP) Ib and GP IIb-IIIa, leading to the transmembrane influx of Ca2+ and the activation of protein kinase C. To investigate this further,...

Circulating tumor cells (CTCs) are the primary targets of cancer treatment as they cause distal metastasis. However, how CTCs response to exercise-induced high shear stress is largely unknown. To study the effects of hemodynamic microenvironment on CTCs, we designed a microfluidic circulatory system that produces exercise relevant shear stresses. We explore the effects of shear stresses on brea...

This study deals with the applications of a trigonometric shear deformation theory considering the effect of the transverse shear deformation on the static flexural analysis of the soft core sandwich beams. The theory gives realistic variation of the transverse shear stress through the thickness, and satisfies the transverse shear stress free conditions at the top and bottom surfaces of the bea...

Colloidal gels respond as soft solids at rest, whereas they flow liquids under external shear. Starting from a fluidized state an applied shear rate ${\stackrel{\ifmmode \dot{}\else \.{}\fi{}}{\ensuremath{\gamma}}}_{p}$, abrupt cessation triggers liquid-to-solid transition during which the stress relaxes towards so-called residual ${\ensuremath{\sigma}}_{\mathrm{res}}$ that tallies macroscopic ...

Virchow rightly recognised that blood flow plays an important role in thrombosis. The roles of blood flow in haemostasis, and in arterial, intra-cardiac, and venous thrombosis are reviewed. In streamline (laminar) flow, shear stresses are maximal at the vessel wall, and affect endothelial cell morphology and function (e.g. secretion of NO, prostacyclin,t-PA and vWF). Platelets are also concentr...

The present study introduces a generalized 2-unknown’s higher order shear deformation theory (HSDT) for isotropic and orthotropic plates. The well-known Shimpi’s two-unknown's HSDT is reproduced as a special case. Reddy’s shear strain shape function (SSSF) is also adapted to the present generalized theory. The results show that both Shimpi and the adapted Reddy’ HSDT are essentially the same, i...

BACKGROUND Pelvic incidence, sacral slope and slip percentage have been shown to be important predicting factors for assessing the risk of progression of low- and high-grade spondylolisthesis. Biomechanical factors, which affect the stress distribution and the mechanisms involved in the vertebral slippage, may also influence the risk of progression, but they are still not well known. The object...

BACKGROUND Reports including our own describe that intravascular hemolysis increases the risk of thrombosis in hemolytic disorders. Our recent study shows that plasma Hb concentrations correlate directly with platelet activation in patients with paroxysmal nocturnal hemoglobinuria (PNH). The binding of Hb to glycoprotein1bα (GP1bα) increases platelet activation. A peptide AA1-50, designed from ...

BACKGROUND AND PURPOSE Vascular shear stress is essential for maintaining the morphology and function of endothelial cells. We hypothesized that shear stress in the internal carotid artery (ICA) may differ between patients with ischemic stroke and healthy control subjects. METHODS ICA shear stress was calculated in 143 controls and 122 patients with ischemic stroke who had a normal ICA or an ...

Offshore wind turbine (OWT) foundations are subjected to a combination of cyclic and dynamic loading arising from wind, wave, rotor and blade shadowing. Under cyclic loading, most soils change their characteristics including stiffness, which may cause the system natural frequency to approach the loading frequency and lead to unplanned resonance and system damage or even collapse. To investigate...